В 52 Virology in schemes and tables : tutorial :[textbook for classroom and extracurricular work of Englis-speaking students in Microbiology, Virology and Immunology of higher medical educational institutions of the IV level of accredation - graduates of master's degree studying in study in specialties 221 "Dentistry" and 222 ''Medicine''] / M. O. Faustova, M. M. Anannieva, G. A. Loban', V. I. Fedorchenko ; Ministry of Health of Ukraine, Poltava State Medical University. - Lviv : Magnolia 2006, 2021. - 110 p. : scheme, tabl., il. ; 21 см. - На англ. мові. - References: p. 110. - 300 прим.. - ISBN 978-617-574-214-3 : 250.00 грн. Переклад назви: Вірусологія/Вірологія в схемах і таблицях: підручник / М. Фаустова та ін.
Рубрики: ВІРУСОЛОГІЯ(АНГЛ)--Підручник Кл.слова (ненормовані): підручники Анотація: CONTENT PREFACE.....................6 A LIST OF ABBREVIATIONS............ 7 SECTION 1. GENERAL VIROLOGY........ ..... .... 8 1.1. FEATURES OF VIRUSES .............8 1.2. PROPERTIES OF UNICELLULAR MICROORGANISMS AND VIRUSES.......... 8 1.3. VIRAL STRUCTURE...............9 1.4. SCHEMATIC VIEW OF SIMPLE (NAKED) VIRUS....9 1.5. SCHEMATIC VIEW COMPLEX (ENVELOPED) VIRUS9 1.6. COMPONENTS OF THE VIRION ......... 10 1.7. DIFFERNCES IN NAKED AND ENVELOPED CAPSID VIRUSES ................. 10 1.8. VIRUS GENOMES ................. 11 1.9. PROTEIN COAT (CAPSID)............ 11 1.10. VIRUS-HOST INTERACTION.......... 12 1.11.TYPES OF VIRUS-HOST INTERACTION AT THE CELLULAR LEVEL............... 12 1.12. STAGES OF VIRAL REPLICATION......... 13 1.13. STAGES OF VIRAL REPLICATION ......... 13 1.14. PROGRESSION OF VIRAL DISEASE......... 13 1.15 MEANS OF ANTIVIRAL IMMUNE RESPONSE ... 14 1.16. HOST DEFENSES TO VIRUSES ......... 14 1.17. FUNCTIONS OF INTERFERONS........... 15 1.18. TYPES OF INTERFERONS ............ 15 1.19. MEHANISMS OF ACTION OF INTERFERON ..... 15 1.20. NATURAL KILLER (CYTOTOXIC) CELLS .... 16 1.21. THE MAIN ACTIVITY OF NK CELLS:....... 16 1.22. ANTIBODY-DEPENDENT CELLULAR CYTOTOXITY.................. 16 1.23. STAGES OF CONTACT CYTOLYSIS:......... 17 1.24. VIRAL CULTIVATION.............. 17 1.25. CELL CULTURE................ 17 1.26. VIRAL DETECTION (INDICATION)........ 18 1.27. HEMAGGLUTINATION TEST IN VIROLOGY..... 18 1.28. VIRUS IDENTIFICATION.............. 18 1.29. HEMAGGLUTINATION INHIBITION TEST (HI).... 19 1.30. SEROLOGICAL REACTIONS IN VIROLOGY... 19 1.31. GENETIC METHODS ...............28 1.32. TERMS ....................28 1.33. TYPES OF REACTIONS ..............29 1.34. IMMUNOBLOTTING................ 32 1.35. TYPES OF BLOTTING..............34 1.36. SCHEMATIC VIEW OF WESTERN BLOT .......34 1.37. ANOTHER MOLECULAR METHODS........35 SECTION 2. SFESIAL VIROLOGY................. 36 2.1.ORTHOMYXOVIRUSES.............36 2.2. PARAMYXOVIRUSES................40 2.3. PICORNAVIRUSES................42 2.4. CALICIVIRUSES, REOVIRUSES (ROTAVIRUSES) AND ASTROVIRUSES - CAUSATIVE AGENTS OF NON-BACTERIAL ACUTE DIARRHEA .................48 2.5. CORONAVIRUSES ................53 2.6. ARTROPOD-BORN AND RODENT-BORN VIRUSES. 57 2.7. FILOVIRUSES ..................63 2.8. RETROVIRUSES.................66 2.9. HEPATITIS VIRUSES ...............72 2.10. HERPESVIRUSES................79 2.10. PARVOVIRUSES.................. 86 2.12. HUMAN PAPILLOMAVIRUSES (HPVS).......89 2.13. HUMAN ADENOVIRUSES ............92 2.14. PRIONS......................97 SECTION 3. KROK-1 TESTS ON VIROLOGY........... 101 REFERENCES.................... 110 Дод.точки доступу: Faustova, M. O. Фаустова Марія Олексіївна Anannieva, M. M. Ананьєва Майя Миколаївна Loban', G. A. Лобань Галина Андріївна Fedorchenko, V. I. Федорченко Віра Іванівна Poltava State Medical University Примірників всього: 40 ЧЗ (1), Наук.Аб. (3), Гурт.4 (1), Уч.Аб. (35) Вільні: ЧЗ (1), Наук.Аб. (3), Гурт.4 (1), Уч.Аб. (35) |
М 42 Medical microbiology, virology and immunology : The textbook for English-speaking students of higher medical educational institutions / ed. V. P. Shyrobokov ; T. V. Andrianova, V. V. Bobyr, V. V. Danyleichenko at al. - Vinnytsia : Nova Knyha, 2019. - 740 p. : il. - На англ. мові. - Bibliography: p. 721. - Subject index: p. 723-740. - ISBN 978-966-382-800-8 : 790.00 грн., 820.00 грн. Переклад назви: Медична мікробіологія, вірусологія та імунологія: підручник / за ред. В. П. Широбокова
Рубрики: МІКРОБІОЛОГІЯ(АНГЛ)--Підручник ВІРУСОЛОГІЯ(АНГЛ)--Підручник ІМУНОЛОГІЯ(АНГЛ)--Підручник Кл.слова (ненормовані): національний підручник(англ) -- підручники(англ) Анотація: The textbook was compiled in accordance with officially approved teaching programs for microbiology, virology and immunology in all faculties of higher medical schools. Questions of general microbiology (basic methods of studying microorganisms, morphology, structure and classification of bacteria, their physiology, the influence of physical, chemical and biological factors on microorganisms, microbial genetics and biotechnology, antimicrobials and the concept of infection) and special microbiology (morphology, physiology, pathogenic properties of pathogens of many infectious diseases, modern methods of their diagnostics, specific prevention and therapy). The textbook also contains sections on virology, protozoology, mycology and helminthology, which examine the basic biological properties of the causative agents and the diseases they cause. A significant part of the textbook is devoted to questions of immunology (nonspecific resistance of the organism, the doctrine of antigens, the immune system of the body, immune response, immunity reactions, allergy and other types of immune responses, immunodiagnostics and immunocorrection, immunoprophylaxis and immunotherapy). The textbook contains sections on clinical and sanitary microbiology, examines the ecology of microorganisms, the normal microbiota of the human body and the effect of microorganisms on the fetus. Separate sections are devoted to the microbiota of the oral cavity and microbiological research in stomatological and pharmaceutical fields. The textbook is intended for students of medical universities, relevant departments of higher education of doctors, interns and microbiologists of all specialties. Full contents Foreword ...............................................................20 List of abbreviations and symbols...............................................21 Part І. General microbiology Chapter 1. The world of microorganisms and its significance .....................................26 (V. P. Shyrobokov) 1.1. The role of microbes in the biosphere and human life. Importance of the modern medical microbiology............26 1.2. History of the microbiology, virology and immunology development .............................29 Chapter 2. Microscopic methods of the investigation of microorganism................................41 (V. P. Shyrobokov, V. V. Bobyr, I. P. Oleksiienko, V. A. Poniatovskyi) 2.1. Methods of the light microscopy ...............................................41 2.2. Luminescence microscopy...................................................43 2.3. Electron microscopy......................................................43 2.4. Confocal laser scanning microscopy...............................................45 2.5. X-ray structure analysis......................................................45 2.6. Atomic-force microscopy .....................................................45 2.7. Super-fluorescent high-resolution microscopy .........................................46 Chapter 3. The morphology, structure and classification of bacteria..................................47 3.1. Morphology and structure of bacteria (Y. L. Kryvorutchenko)...................................47 3.2. Principles of the systematization, taxonomy and nomenclature of microbes. The classification of bacteria (V. P. Shyrobokov, Y. L. Kryvorutchenko, M. V. Shylov)......................................54 Chapter 4. Physiology of bacteria....................................................59 (V. G. Voitsekhovsky, V. P. Shyrobokov) 4.1. Metabolism of bacteria ......................................................59 4.2. Enzymes of bacteria ......................................................59 4.3. Nutrition of bacteria......................................................60 4.4. Energetic metabolism (biological oxidation)...........................................62 4.4.1. Catabolism of carbohydrates...............................................62 4.4.2. Oxidative phosphorylation. Breathing............................................62 4.4.3. Substrate phosphorylation. Fermentation..........................................64 4.5. Constructive metabolism.....................................................65 4.5.1. Biosynthesis of amino acids and proteins.........................................65 4.5.2. Biosynthesis of carbohydrates...............................................66 4.5.3. Biosynthesis of fatty acids and lipids............................................66 4.5.4. Biosynthesis of nucleotides and nucleic acids......................................66 4.6. Chemical structure of bacteria .................................................67 4.7. Pigments of microorganisms.................................................67 4.8. Luminescent bacteria and aroma-forming bacteria.......................................68 4.9. Growth, propagation and development of bacteria......................................68 4.10. Cultivation of bacteria......................................................69 4.11. Assessment of the bacterial growth and development ......................................70 4.12. Growth media .........................................................70 4.13. Cultural properties of bacteria..................................................71 4.14. Cultivation of obligate anaerobes..............................................72 4.15. Obtaining of pure bacterial cultures.............................................73 4.16. Ethology of microorhanisms..................................................74 Chapter 5. Morphology, physiology and classification of fungi and protozoa .............................78 (A. V. Rudenko, T. V. Andrianova, N. A. Vynohrad) 5.1. Structure of the fungi.......................................................78 9 5.2. Physiological features of microscopic fungi..........................................80 5.3. Fungi classification......................................................81 5.4. Structure and classification of the protozoa ...........................................83 Chapter 6. Morphology, physiology and classification of viruses ...................................85 (V. P. Shyrobokov, I. V. Dziublyk) 6.1. Morphology and structure of viruses..............................................85 6.2. Reproduction. Stages and types of interaction of virus and cell .................................87 6.3. Methods of cultivation and detection of the viruses........................................92 6.3.1. Cultivation in laboratory animals.............................................92 6.3.2. Cultivation in chicken embryos.............................................94 6.3.3. Cultivation in the cell cultures ...............................................94 6.3.4. Identification of isolated viruses .............................................98 6.4. Classification and nomenclature of viruses...........................................99 6.5. Bacteriophages (phages)....................................................100 Chapter 7. The effect of physical, chemical and biological factors on microorganisms ........................104 (G. K. Palii) 7.1. Physical factors........................................................105 7.2. Chemical factors........................................................106 7.3. Biological factors.......................................................106 7.4. Concept of aseptics, antiseptics and disinfection .........................................106 7.5. Sterilization.........................................................107 Chapter 8. Genetics of microbes..................................................110 (V. P. Shyrobokov, A. Y. Tsyhanenko, V. A. Poniatovskyi) 8.1. Structure of the bacterial genome..............................................110 8.1.1. Bacterial chromosome................................................111 8.1.2. Plasmids.........................................................113 8.1.3. Integrons........................................................113 8.1.4. Transposons.....................................................113 8.1.5. IS-elements......................................................114 8.1.6. Temperate bacteriophages................................................114 8.1.7. CRISPR/Cas system of the inheritable immunity in batceria...............................114 8.2. Types of variability in bacteria................................................114 8.2.1. Modifications.....................................................114 8.2.2. Mutations......................................................115 8.2.3. Recombination.....................................................116 8.2.4. Dissociation of bacteria.................................................118 8.3. Genetic methods of investigation of microbes and daignostics..................................119 8.3.1. Polymerase chain reaction (pcR)...........................................119 8.3.2. Method of molecular hybridization............................................120 8.3.3. Restriction analysis....................................................120 8.3.4. Ribotyping and transcription-mediated amplification of ribosomal RNA..........................120 8.4. Genetics of viruses.......................................................120 8.4.1. Features of the viral genome.............................................121 8.4.2. Forms of variability in viruses...............................................122 8.4.3. Dissociation of viruses................................................123 Chapter 9. Biotechnology......................................................125 (V. V. Danyleichenko) 9.1. Definition of biotechnology.................................................125 9.2. Microorganisms in biotechnological processes..........................................125 9.3. Principles of the obtainment of biotechnological preparations................................126 9.4. Genetic engineering biotechnology with the use of microorganisms.............................127 Chapter 10. Antimicrobial medications...............................................130 10.1. Chemotherapy as a science. History of its development (G. K. Palii, V. P. Kovalchuk, V. G. Palii)................130 10.2. Chemotherapeutic drugs (G. K. Palii, V. P. Kovalchuk, V. G. Palii)..............................131 10.3. Antiseptics and disinfectants (G. K. Palii, V. P. Kovalchuk, V. G. Palii).............................132 10 10.4. Antibiotics. Production, classification (A. Y. Tsyhanenko)..................................134 10.4.1. Sources and methods of antibiotic obtainment....................................134 10.4.2. Classification of antibiotics by the mechanism of action on microbial cells......................134 10.4.3. Classification of antibiotics by chemical structure...................................137 10.5. Adverse reactions during antibiotic therapy (A. Y. Tsyhanenko).................................137 10.6. Some principles of rational antibiotic therapy (A. Y. Tsyhanenko) ................................138 10.7. Determination of antibiotic susceptibility pattern in microorganisms (A. Y. Tsyhanenko) ...................138 10.7.1. Diffusion methods..................................................138 10.7.2. Serial dilutions methods................................................139 10.8. Antiviral drugs (V. P. Shyrobokov, I. V. Dziublyk) ......................................139 Chapter 11. Infection ........................................................142 (A. Y. Tsyhanenko) 11.1. Infection process. Definition.................................................142 11.2. Pathogenicity and virulence of microbes. Genetic determinancy................................143 11.3. Factors of pathogenicity and virulence...........................................144 11.4. Role of macroorganism in the infectious process.......................................146 11.5. Role of the environment and social factors in infectious process.................................147 11.6. Forms of infectious process..................................................148 11.7. Persistence of the causative agent in the organism: mechanisms, importance........................149 11.8. Pathogenesis of infectious disease .............................................149 11.9. Stages of pathogenesis and their characteristics........................................150 11.10. Infectious disease: definition, stages, classification.......................................151 11.11. Features of viral infections..................................................152 11.12. Concept of epidemic process...............................................153 Chapter 12. Immunology. Innate nonspecific immunity .......................................155 (Y. L. Kryvorutchenko, V. P. Shyrobokov) 12.1. Immunology as science. Main historical stages........................................155 12.2. Essence, role and evolution of the immunity.........................................156 12.3. Types and forms of immunity and immune reactivity ....................................157 12.4. Nonspecific resistance of the organism, general characteristics................................159 12.5. Factors of nonspecific protection ................................................159 12.5.1. Mechanical (physical) barriers and physicochemical barriers of the human organism...................159 12.5.2. Regulation of the immune system with cytokines ....................................159 12.5.3. Cellular factors of innate immunity .........................................161 12.5.4. Humoral factors of innate immunity ..........................................164 12.5.5. Inflammation ......................................................166 Chapter 13. Study of the antigens.................................................169 (Y. L. Kryvorutchenko) 13.1. Definition of antigens....................................................169 13.2. Concept of antigenicity and immunogenicity..........................................169 13.3. Chemical nature of the antigens. Haptens. Synthetic antigens..................................170 13.4. Antigen determinants, their structure and classification.....................................171 13.5. Specificity of antigens....................................................171 13.6. Classification of antigens....................................................172 13.7. Antigens of the human organism................................................174 13.8. Antigens of microorganisms.................................................177 Chapter 14. Immune system of the organism. Immune response. Reactions of immunity......................179 (V. V. Minukhin) 14.1. Organs of immune system .................................................179 14.2. Cell population of immune systems..............................................182 14.3. Maturation of immunocompetent cells.............................................184 14.4. Recognition of “foreign” and “native”.............................................185 14.5. Patterns of immune response .................................................186 14.6. Production of antibodies....................................................187 14.6.1. Antibodies structure .................................................187 11 14.6.2. Active centers of antibodies. Complete and incomplete antibodies...........................188 14.6.3. Classification of immunoglobulins...........................................189 14.6.4. Antigenic properties of immunoglobulins .......................................190 14.6.5. Mechanism of interaction between antibody and antigen..............................190 14.6.6. Cooperation of immune system cells in formation of antibodies...........................191 14.6.7. Theories of immunity (antibodies diversity)......................................191 14.7. Reactions of cellular immunity ...............................................193 14.8. Regulation of immune reactions...............................................193 14.9. Immune memory cells and secondary immunity.......................................195 14.10. Monoclonal antibodies, production, practical use .....................................195 Chapter 15. Allergy and other types of immune reactions ......................................196 (V. V. Minukhin) 15.1. Local immunity and its patterns................................................196 15.2. Allergy and its role in medicine .................................................198 15.3. Allergens and their properties................................................200 15.4. Type 1 hypersensitivity (anaphylactic reactions) ........................................202 15.5. Type 2 hypersensitivity (cytotoxic allergic reactions)......................................202 15.6. Type 3 hypersensitivity (immune complex reactions).....................................203 15.7. Type 4 hypersensitivity (delayed type) ............................................203 15.8. Diagnostic allergic tests....................................................204 15.9. Methods of desensitization of the organism..........................................205 15.10. Autoimmune pathology...................................................206 15.11. Study of immunological tolerance...............................................207 15.12. Transplantation immunity...................................................208 15.13. Antitumor immunity ....................................................208 15.14. Patterns of immunology of pregnancy ............................................209 15.15. Concept of immunodeficiency states............................................210 15.16. Features of protection mechanisms in bacterial, virus, fungi and protozoa infections (V. V. Danyleichenko)..........211 15.16.1. Mechanisms of protection against bacteria .....................................211 15.16.2. Mechanisms of antiviral protection..........................................212 15.16.3. Features of immunity in parasitic infections .....................................213 15.16.4. Features of immunity in fungal infections ......................................214 Chapter 16. Immunodiagnostics and immune correction .......................................215 (Y. L. Kryvorutchenko) 16.1. Principles and methods of immunodiagnostics.......................................215 16.2. Serologic tests, their characteristics, mechanism, classification and diagnostic value.......................216 16.2.1. Diagnostic sera and their production ........................................217 16.2.2. Diagnosticums...................................................218 16.2.3. Agglutination test...................................................218 16.2.4. Precipitation test ....................................................219 16.2.5. Immune haemolysis test ...............................................221 16.2.6. Complement fixation test ...............................................222 16.2.7. Neutralization test ..................................................222 16.2.8. Haemagglutination inhibition test...........................................224 16.2.9. Virus neutralization test.................................................225 16.2.10. Immunoelectrophoresis ................................................226 16.2.11. Immune electronic microscopy............................................226 16.2.12. Indirect haemagglutination test..........................................226 16.2.13. Immune adhesion test.................................................228 16.2.14. Immune immobilization test..............................................228 16.2.15. Immunofluorescence test (IFT).............................................228 16.2.16. Enzyme immunoassay EIA.............................................229 16.2.17. Radioimmune assay, RIA................................................231 16.2.18. Immunoblotting ..................................................231 16.3. Detection of various classes of immunoglobulins in immunodiagnostics............................232 16.4. Estimation of the immune state of the organism. Principles and methods of immune correction. Immunomodulators and immunosuppressors (S. I. Klymnyuk, Y. L. Kryvorutchenko)........................233 12 Chapter 17. Immunoprophylaxis and immunotherapy ......................................238 (V. P. Shyrobokov, V. V. Bobyr, V. A. Poniatovskyi) 17.1. Role of immunoprophylaxis and immunotherapy in the modern medicine...........................238 17.2. Immunobiological drugs, its definition, classification, characteristics..............................238 17.3. Vaccines, history of vaccinal prevention.............................................239 17.4. Vaccines classification ....................................................240 17.4.1. Live vaccines. The essence of attenuation phenomenon...............................240 17.4.2. Inactivated vaccines .................................................241 17.4.3. Chemical vaccines ..................................................241 17.4.4. Toxoids (anatoxins).................................................242 17.4.5. Genetically engineered vaccines ...........................................243 17.4.6. Fourth generation vaccines ...............................................243 17.5. Ways of vaccines administration...............................................245 17.6. Vaccinations calendar.....................................................245 17.7. Medical and preventive sera.................................................245 Part 2. Special microbiology Chapter 18. Microbiologic diagnostics of infectious diseases...................................250 (G. M. Kremenchutskyi) 18.1. Diagnostic microbiological, virologic and immunologic laboratories..............................250 18.2. Basic, backroom and other laboratories.............................................251 18.3. Regulations of work in microbiological laboratory.......................................252 18.4. Groups of microbes’ pathogenicity.............................................253 18.5. Microbiological diagnostics..................................................253 18.6. Materials for microbiological research. Storage and transport................................254 18.7. Microscopic method of diagnostics...............................................255 18.8. Cultural method......................................................255 18.9. Serological diagnostics.....................................................256 18.10. Allergologic method....................................................256 18.11. Biological method (biotest)................................................256 18.12. Rapid diagnostics of infections...............................................257 18.13. Features of virological methods of diagnostics.........................................257 18.14. Features of microbiological diagnostics of mycoses.....................................258 18.15. Features of microbiologic diagnostics of protozoa infections..................................258 18.16. Features of laboratory diagnostics of bacteria unable of cultivation..............................259 18.17. Genetic methods of microbiological diagnostics........................................259 Chapter 19. Special bacteriology...................................................260 19.1. Gram-positive aerobic and facultative-anaerobic cocci (G. M. Kremenchutskyi).........................260 19.1.1. Staphyloсocci (Staphyloсoccus genus) ..........................................260 19.1.2. Streptococci (Streptococcus genus)..........................................265 19.1.3. Enterococci (Enterococcus genus) ..........................................269 19.1.4. Group of gram-positive catalase-negative cocci: aerococci (Aerococcus genus), leuconostocci (Leuconostocus genus), pediococci (Pediococcus genus), lactococci (Lactococcus genus).............270 19.2. Gram-negative cocci (G. M. Kremenchutskyi).........................................272 19.2.1. Meningococci.....................................................272 19.2.2. Gonococci......................................................274 19.2.3. Anaerobic gram-negative cocci – veillonella (Veillonella genus).............................276 19.3. Anaerobic gram-positive cocci (G. M. Kremenchutskyi)....................................278 19.4. Facultative-anaerobic gram-negative bacilli (G. M. Kremenchutskyi)............................278 19.4.1. Enterobacteriaceae family. General characteristics of enterobacteria, their evolution.................278 19.4.1.1. Escherichia (Escherichia genus).........................................279 19.4.1.2. Salmonella (Salmonella genus).........................................282 19.4.1.3. Shigella (Shigella genus)..........................................286 19.4.1.4. Klebsiella (Klebsiella genus)..........................................288 19.4.1.5. Proteus (Proteus genus)............................................289 19.4.1.6. Yersinia (Yersinia genus) ...........................................290 13 19.4.1.7. Serratia (Serratia genus) (V. P. Shyrobokov, G. S. Dyment).............................293 19.4.2. Vibrionaceae family...................................................294 19.4.2.1. Cholera vibrios (Vibrio genus) (G. M. Kremenchutskyi, A. A. Furman) .......................295 19.4.2.2. Parahemolytic vibrios (Vibrio genus).....................................297 19.4.3. Aeromonas (aeromonas genus)...........................................299 19.4.4. Plesiomonas (plesiomonas genus) ............................................300 19.4.5. Haemophilic bacteria haemophilus genus .....................................300 19.4.5.1. Haemophilus influenzae............................................300 19.4.5.2. Haemophilus ducreyi ...........................................302 19.4.6. Pasteurella (pasteurella genus).............................................303 19.4.7. Calymmatobacteria (calymmatobacterium genus)....................................304 19.4.8. Eikenella (eikenella genus)...............................................304 19.5. Gram-negative aerobic bacilli (G. K. Palii, V. P. Kovalchuk) ..................................305 19.5.1. Bordetella (Bordetella genus).............................................305 19.5.1.1. Bordetella pertussis............................................305 19.5.1.2. Bordetella parapertussis and other Bordetellas.................................307 19.5.2. Brucella (brucella genus)................................................307 19.5.2.1. Brucella melitensis .............................................308 19.5.2.2. Brucella abortus...............................................310 19.5.2.3. Brucella suis, other Brycellae.........................................311 19.5.3. Francisella (Francisella genus)............................................311 19.5.3.1. Francisella tularensis............................................311 19.5.4. Legionella (legionella genus).............................................313 19.5.4.1. Legionella pneumophila............................................313 19.5.5. Bartonella (bartonella genus) ............................................315 19.5.5.1. Bartonella henselae..............................................315 19.5.5.2. Bartonella baciliformis............................................316 19.5.5.3. Bartonella quintana .............................................316 19.6. Gram-negative nonfermentative bacilli (V. G. Voitsekhovsky)..................................316 19.6.1. Pseudomonas (pseudomonas genus)..........................................316 19.6.1.1. Pseudomonas aeruginosa (blue pus bacillus) .................................316 19.6.2. Burkholderia burkholderia genus ...........................................318 19.6.2.1. Burkholderia mallei – pathogen of glanders...................................318 19.6.2.2. Burkholderia pseudomallei – causative agent of melioidosis ...........................320 19.6.2.3. Burkholderia cepacia (old Pseudomonas cepacia) ................................320 19.6.3. Кingella (кingella genus) ...............................................320 19.6.4. Мoraxella (мoraxella genus) ..............................................321 19.6.5. Аcinetobacter (аcinetobacter genus)..........................................322 19.7. Gram-negative anaerobic bacilli (V. V. Danyleichenko) .....................................323 19.7.1. bacteroides genus...................................................324 19.7.2. porphyromonas genus.................................................326 19.7.3. prevotella genus...................................................326 19.7.4. leptotrichia genus..................................................326 19.7.5. fusobacterium genus................................................326 19.7.6. bilophila genus..................................................327 19.8. Gram-positive aerobic spore forming bacilli (V. G. Voitsekhovsky)...............................327 19.8.1. Bacillus anthracis – pathogen of anthrax.........................................327 19.8.2. Other kinds of gram-positive aerobic spore forming bacteria..............................330 19.9. Gram-positive anaerobic spore forming bacilli (V. V. Danyleichenko)............................333 19.9.1. Clostridia of gas gangrene...............................................333 19.9.1.1. Clostridium perfringens..........................................333 19.9.1.2. Clostridium novyi (oedematiens)........................................335 19.9.1.3. Clostridium septicum ...........................................335 19.9.1.4. Clostridium hystoliticum ...........................................335 19.9.1.5. Clostridium sordellii..............................................335 19.9.1.6. Clostridium sporogenes..........................................335 19.9.1.7. Clostridium chauvoei ...........................................335 19.9.1.8. Clostridium fallax ...............................................335 19.9.1.9. Clostridium bifermentans.........................................335 19.9.2. Clostridium difficile – pathogen of pseudomembranous enterocolitis...........................336 19.9.3. Clostridium tetani – pathogen of tetanus .......................................336 19.9.4. Clostridium botulinum – pathogen of botulism......................................338 14 19.10. Gram-positive bacilli (A. Y. Tsyhanenko)...........................................339 19.10.1. Listeria (listeria genus).................................................339 19.10.1.1. Listeria monocytogenes..........................................339 19.10.2. Corynebacterium (corynebacterium genus)......................................342 19.10.2.1. Corynebacterium diphtheriae ........................................342 19.10.2.2. Coryneform bacteria............................................345 19.10.3. Mycobacterium (mycobacterium genus) (V. V. Danyleichenko, V. P. Shyrobokov)....................346 19.10.3.1. Mycobacterium tuberculosis........................................346 19.10.3.2. Mycobacterium bovis ...........................................350 19.10.3.3. Mycobacterium africanum........................................350 19.10.3.4. Mycobacterium microti...........................................350 19.10.3.5. Mycobacterium leprae..........................................350 19.10.3.6. Other mycobacteria (old name – atypical mycobacteria)............................351 19.10.4. Actinomycetes (actinomyces genus) (A. Y. Tsyhanenko) ...............................352 19.10.4.1. Actinomyces israelii and other actinomycetes ...............................352 19.10.5. Nocardia (nocardia genus) (A. Y. Tsyhanenko)...................................353 19.10.6. Eubacterium (eubacterium genus). Mobiluncus (mobiluncus genus) gardnerella (gardnerella genus) (V. V. Danyleichenko)...................................................355 19.11. Spirochetes and other spiral and flamboyant microorganisms...............................356 19.11.1. Treponema (treponema genus) (V. P. Shyrobokov, T. N. Tarasov, M. V. Shylov)...................357 19.11.1.1. Treponema pallidum, sub-species pallidum – pathogen of syphilis .......................357 19.11.1.2. The pathogens of tropical treponematoses ................................358 19.11.2. Borrelia (borrelia genus) (V. P. Shyrobokov, T. N. Tarasov, M. V. Shylov) ........................358 19.11.2.1. Borrelia recurrentis – causative agent of epidemic relapsing fever.......................358 19.11.2.2. Borrelia duttoni, В. persica etc. – pathogens of endemic relapsing fever ....................359 19.11.2.3. Borrelia burgdorferi, В. garini, and В. afzelii, B. spielmanii, B. bovariensis – pathogens of Lyme disease ......359 19.11.3. Leptospira (Leptospira genus) (V. P. Shyrobokov, T. N. Tarasov, M. V. Shylov) ......................360 19.11.3.1. Leptospira interrogans............................................361 19.11.4. Campylobacter (campylobacter genus) (V. V. Danyleichenko)............................361 19.11.5. Helicobacter (helicobacter genus) (V. V. Danyleichenko)................................362 19.11.6. Spirillum (spirillum genus) (M. V. Shylov) .......................................363 19.11.6.1. Spirillum minus..............................................363 19.12. Rickettsia (rickettsiaceae family) (V. V. Danyleichenko)...................................364 19.12.1. Rickettsiae of the group of typhus fever.......................................366 19.12.1.1. Rickettsia prowazekii ............................................366 19.12.1.2. Rickettsia typhi (syn.: mooseri) .........................................367 19.12.1.3. Rickettsia felis..............................................367 19.12.2. Rickettsiae of the group of spotted fever .......................................367 19.12.2.1. Rickettsia sibirica..............................................367 19.12.2.2. Rickettsia conori...............................................368 19.12.2.3. Rickettsia rickettsii ..............................................368 19.12.2.4. Rickettsia akari ..............................................368 19.12.3. Orientia tsutsugamushi ................................................368 19.12.4. Ehrlichia........................................................368 19.12.4.1. Neorickettsia sennetsu..........................................369 19.12.4.2. Ehrlichia chaffeensis...........................................369 19.12.4.3. Anaplasma phagocytophilum .......................................369 19.12.5. Coxiellae.......................................................369 19.12.5.1. Coxiella burnetii is causative agent of Q-fever................................369 19.13. Chlamydia (order of Chlamydiales) (G. K. Palii, Z. N. Nekhoroshykh, V. P. Kovalchuk).....................370 19.13.1. Chlamydia trachomatis................................................371 19.13.2. Chlamydophila pneumoniae ............................................373 19.13.3. Chlamidophila psittaci...............................................374 19.14. Mycopasmas (class of Mollicutes) (A. V. Rudenko)......................................375 19.14.1. Mycoplasma pneumoniae ..............................................377 19.14.2. Mycoplasma hominis, mycoplasma genitalium .....................................378 19.14.3. Ureaplasma urealyticum / parvum...........................................378 Chapter 20. Special virology ......................................................380 (V. P. Shyrobokov, I. V. Dziublyk) RNA viruses..............................................................380 20.1. Picornaviruses (family of Picornaviridae) ...........................................380 15 20.1.1. Enterovirus (Enterovirus genus)............................................381 20.1.2. Rhinoviruses (Rhinovirus genus).............................................387 20.1.3. Aphthoviruses (Aphthovirus genus) .........................................388 20.1.4. Kobuviruses (Kobuvirus genus) ............................................388 20.2. Reoviruses (family of Reoviridae)...............................................389 20.2.1. Rotaviruses (Rotavirus genus)............................................390 20.3. Bunyaviruses (Bunyaviridae family).............................................394 20.3.1. Rift-vally fever virus...................................................396 20.3.2. Virus of the crimean-congo haemorrhagic fever .....................................397 20.3.3. Viruses of hfrs and hantavirus pneumonia .......................................397 20.3.4. Viruses of the california encephalitis complex ....................................399 20.4. Togaviruses (Togaviridae family) (N. A. Vynohrad, V. P. Shyrobokov)..............................399 20.4.1. Viruses of the Alphavirus genus...........................................400 20.4.2. Rubivirus genus.....................................................403 20.5. Flaviviruses (Flaviviridae family) (N. A. Vynohrad, V. P. Shyrobokov) ..............................404 20.5.1. Flavivirus genus.....................................................404 20.6. Arenaviruses (Arenaviridae family) (N. A. Vynohrad, I. V. Dziublyk, V. P. Shyrobokov) ....................409 20.6.1. Arenavirus genus..................................................409 20.7. Orthomyxoviruses – viruses of influenza (Orthomyxoviridae family) (V. P. Shyrobokov, I. V. Dziublyk, S. I. Klymnyuk, K. I. Lipatnikova)......................................................411 20.8. Paramyxoviruses (Paramyxoviridae family)...........................................422 20.8.1. Parainfluenza viruses................................................424 20.8.2. Viruses of parotitis...................................................425 20.8.3. Virus of measles and subacute sclerosing panencephalitis..............................426 20.8.4. Respiratory syncytial virus ..............................................428 20.8.5. Metapneumovirus .................................................429 20.9. Rhabdoviruses (Rhabdoviridae family).............................................429 20.9.1. Rabies virus.......................................................430 20.9.2. Vesicular stomatitis virus...............................................433 20.10. Filoviruses (Filoviridae family) ...............................................434 20.10.1. Marburg and ebola viruses .............................................434 20.11. Coronaviruses (Coronaviridae family).............................................438 20.11.1. SARS associated coronavirus Urbani ........................................439 20.11.2. Causative agent of the middle east respiratory syndrome (MERS-CoV) ........................440 20.12. Retroviruses (Retroviridae family) ..............................................441 20.12.1. Human immunodeficiency virus (HIV 1/2)......................................441 20.12.2. Human T-cell leukemia-lymphoma virus......................................448 20.13. Caliciviruses (Caliciviridae family)..............................................449 20.14. Astroviruses (Astroviridae family)...............................................450 DNA viruses .............................................................451 20.15. Parvoviruses (Parvoviridae family).............................................451 20.15.1. Human parvovirus В19................................................452 20.15.2. Human parvovirus HBOV...............................................454 20.15.3. Adeno-associated dependoviruses...........................................454 20.16. Adenoviruses (Adenoviridae family).............................................455 20.17. Herpesviruses (Herpesviridae family)..............................................457 20.17.1. Herpes simplex viruses................................................460 20.17.2. Varicella-zoster-virus..................................................464 20.17.3. Epstein – Barr virus..................................................466 20.17.4. Cytomegalovirus...................................................467 20.17.5. Herpesviruses of 6, 7 and 8 types...........................................468 20.18. Poxviruses (Poxviridae family)...............................................469 20.18.1. Smallpox virus.....................................................471 20.18.2. Vaccinia virus ...................................................474 20.18.3. Virus of contagious mollusc ............................................474 20.18.4. Viruses of cowpox, monkeypox, Orf virus, etc. ....................................475 20.19. Papilloma- and Polyomaviruses (Papillomaviridae and Polyomaviridae family's).........................475 16 Hepatitis viruses..........................................................476 20.20. Obligate hepatotropic viruses.................................................476 20.20.1. Hepatitis A virus....................................................476 20.20.2. Hepatitis B virus ....................................................478 20.20.3. Hepatitis C virus ...................................................485 20.20.4. Hepatitis D virus....................................................490 20.20.5. Hepatitis E virus ....................................................492 20.20.6. Hepatitis G virus ...................................................494 20.20.7. Hepatitis TT virus .................................................495 20.20.8. Hepatitis SENV virus ..................................................496 Oncogenic viruses .........................................................497 (N. A. Vynohrad, V. P. Shyrobokov) 20.21. RNA oncoviruses......................................................498 20.21.1. Retroviridae family ...................................................498 20.22. DNA oncoviruses.....................................................499 20.22.1. Papillomaviridae family................................................499 20.22.2. Polyomaviridae family ...............................................500 20.22.3. Herpesviridae family ................................................500 20.22.4. Hepadnaviridae family...............................................501 20.22.5. Poxviridae family. Virus of contagious mollusc.....................................501 Causative agents of slow viral infections...............................................502 (N. A. Vynohrad, V. P. Shyrobokov) 20.23. Measles virus and SSPE ..................................................503 20.24. Rubella virus........................................................503 20.25. Tick-borne encephalitis virus................................................503 20.26. Herpes viruses.......................................................504 Prions.................................................................504 (N. A. Vynohrad) Chapter 21. Mycology........................................................507 (A. V. Rudenko, E. Z. Koval) 21.1. Causative agents of superficial mycoses (keratomycoses)..................................507 21.1.1. Pityriasis versicolor (scaly) – malassezia furfur (synonyms: ptyrosporium orbiculare, ptyrosporium ovale) ........507 21.1.2. Black piedra......................................................508 21.1.3. White piedra.....................................................508 21.2. Dermatomycoses.......................................................509 21.2.1. Microsporia.......................................................509 21.2.2. Trichophytosis....................................................511 21.2.3. Epidermophytosis...................................................513 21.3. Causative agents of subcutaneous mycoses..........................................513 21.3.1. Sporotrichosis.....................................................513 21.3.2. Chromomycosis (Chromoblastomycosis)........................................515 21.3.3. Mycetoma (eumycetoma)................................................517 21.3.4. Phaeohyphomycoses ..................................................518 21.3.5. Hyalohyphomycoses ................................................524 21.4. Causative Agents of deep (visceral) mycoses. Extremely dangerous mycotic infections......................528 21.4.1. Histoplasmosis .....................................................529 21.4.2. Blastomycosis (north american blastomycosis).....................................530 21.4.3. Coccidioidosis.....................................................530 21.4.4. Paracoccidioidosis (American blastomycosis)....................................532 21.4.5. Adiaspiromycosis....................................................532 21.5. Causative agents of opportunistic (systemic) mycoses.....................................533 21.5.1. Candidiasis.....................................................533 21.5.2. Zygomycosis (Mucormycosis, Mucorosis).......................................535 21.5.3. Aspergillosis.....................................................539 21.5.4. Penicillosis......................................................543 17 21.5.5. Fusariosis........................................................544 21.5.6. Pneumocystosis ...................................................546 21.6. Mycotoxicoses. Fungi-producers of mycotoxins.........................................547 21.6.1. Sporotrichiella toxicosis.................................................550 21.6.2. Fusariograminearotoxicosis and fusarionivaletoxicosis..................................550 21.6.3. Citreoviridetoxicosis (Penicillium citreo-viride).....................................550 21.6.4. Ergotism ......................................................550 21.6.5. Aflatoxicoses....................................................551 21.6.6. Stachybotryotoxicosis ................................................552 21.7. Non-classified pathogenic fungi...............................................552 21.7.1. Lacazia loboi.....................................................552 21.7.2. Rhinosporidium seeberi................................................552 21.8. Fungal allergies........................................................553 21.9. Peculiarities of the methods of fungi isolation and its identification.............................554 21.10. Antifungal preparations for treatment of mycoses.....................................556 Chapter 22. Protozoology......................................................559 (N. A. Vynohrad) 22.1. Sarcodic..........................................................561 22.1.1. Pathogen of amebiasis – Entamoeba histolytica ....................................561 22.1.2. Free-living pathogenic amoebae...........................................562 22.2. Flagellae ............................................................564 22.2.1. Causative agents of leishmaniasis (Leischmania spp.)................................564 22.2.2. Pathogens of trypanosomiasis ............................................566 22.2.3. Pathogen of giardiasis of Giardia lamblia........................................567 22.2.4. Pathogens of trichomoniasis.............................................568 22.3. Sporozoa ...........................................................569 22.3.1. Pathogen of malaria .................................................569 22.3.2. Pathogen of toxoplasmosis – Toxoplasma gondii ..................................572 22.3.3. Pathogens of sarcocystosis – Sarcocystissuihominis and Sarcocystis hominis.....................573 22.3.4. Pathogens of isosporosis – Isospora belli and Isospora natalensis.............................574 22.3.5. Pathogens of cryptosporidiosis – Cryptosporidium hominis and Cryptosporidium parvum.................574 22.3.6. Pathogen of cyclosporosis – Cyclospora cayetanensis................................575 22.3.7. Pathogens of babesiosis – Babesia microti and Babesia divergens............................576 22.4. Ciliate............................................................576 22.4.1. Pathogen of balantidiasis – Balantidium coli.....................................576 22.5. Microsporidia ........................................................577 22.5.1. Pathogens of microsporidiosis.............................................577 22.6. Blastocysts...........................................................579 22.6.1. Pathogen of blastocystosis – Blastocystis hominis....................................579 Chapter 23. Helminths .........................................................580 (N. A. Vynohrad) 23.1. Structure and classification of helminths...........................................580 23.2. Nematodes..........................................................581 23.2.1. Pathogens of ancylostomiasis – Ancylostoma duodenale and Necator americanus....................581 23.2.2. Pathogen of ascariasis – Ascaris lumbricoides....................................582 23.2.3. Pathogen of dracunculiasis (guinea-worm disease) – Dacunculus medinensis .....................582 23.2.4. Pathogen of enterobiosis – Enterobius vermicularis.................................583 23.2.5. Pathogens of strongyloidiasis – Strongyloides stercoralis................................584 23.2.6. Pathogen of toxocariasis – Toxocara canis.......................................585 23.2.7. Pathogens of trichinosis – Trichinella spiralis and Trichinella pseudospiralis......................585 23.2.8. Pathogen of trichocephalosis – Trichocephalus trichiurus...............................586 23.3. Cestodes............................................................586 23.3.1. Pathogen of alveococcosis – Alveococcus multiloсularis multiloсularis.........................587 23.3.2. Pathogen of hymenolepiasis – Hymenolepis nana ...................................588 23.3.3. Pathogen of diphyllobothriasis – Diphyllobotrium latum................................588 23.3.4. Pathogen of echinococcosis – Echinococcus granulosus.................................589 23.3.5. Pathogen of taeniarhynchiasis – Taeniarhynchus saginatus................................589 18 23.3.6. Pathogen of taeniasis and cysticercosis – Tаenia solium.................................590 23.4. Trematodes..........................................................591 23.4.1. Pathogens of opisthorchiasis – Opisthorchis felineus and Opisthorchis viverrini ....................591 23.4.2. Pathogens of fascioliasis – Fasciola hepatica and Fasciola gigantica ..........................592 23.4.3. Pathogens of schistosomiasis – Schistosoma haematobium, Schistosoma mansoni, Schistosoma jаponicum, Schistosoma intercalatum, Schistosoma malayensis, Schistosoma mecongi, Schistosoma matteei ................592 23.5. Antihelmintic drugs.....................................................594 Chapter 24. Clinical microbiology ...................................................596 (S. I. Klymnyuk) 24.1. Opportunistic pathogenic microorganisms...........................................597 24.2. Opportunistic infections..................................................598 24.3. Etiology of bacteremia and sepsis...............................................599 24.4. Etiology of opportunistic purulent-inflammatory infections...................................600 24.4.1. Etiology of wound and burn infection..........................................600 24.4.2. Etiology of purulent inflammation of various organs and tissues.............................601 24.4.3. Etiology of opportunistic bronchopulmonary infections.................................602 24.4.4. Etiology of opportunistic urological infections.....................................603 24.4.5. Etiology of opportunistic gynecological infections...................................604 24.4.6. Etiology of opportunistic infections of the central nervous system ............................604 24.4.7. Etiology of opportunistic intestinal infections....................................605 24.5. Dysbiosis (dysbacteriosis)...................................................606 24.6. Nosocomial (hospital, hospital-acquired, iatrogenic) infections................................607 24.7. Microbiological criteria for etiological role of opportunistic infections..............................609 24.8. Epidemiological control in the system of measures for prevention of nosocomial infections.................610 Chapter 25. Microorganisms and fetus ...............................................611 (O. I. Evtushenko) 25.1. Etiology...........................................................611 25.2. Epidemiology........................................................613 25.3. Pathogenesis.........................................................613 25.4. Principles of microbiological diagnosis of intrauterine infections...............................615 25.5. Viral infections.......................................................615 25.5.1. Cytomegalovirus infection ..............................................615 25.5.2. Herpes.......................................................615 25.5.3. Varicella virus (herpes zoster) infection.........................................616 25.5.4. Rubella .........................................................616 25.5.5. Hiv infection....................................................616 25.5.6. Viral hepatitides....................................................616 25.5.7. Enteroviruses......................................................617 25.5.8. Parvovirus infection...................................................617 25.6. Bacterial infections.......................................................617 25.7. Fungal infections........................................................618 25.8. Protozoal infections.....................................................619 Chapter 26. Ecology of microorganisms..............................................620 (S. I. Klymnyuk) 26.1. The role of microorganisms in the biosphere, the cycle of substances in nature ........................620 26.2. Basic ecological concepts...................................................624 26.3. Ecological relations in microbiocenoses............................................624 26.4. Soil microbiota.........................................................625 26.5. Microbiota of water reservoirs................................................627 26.6. Air microbiota .......................................................629 26.7. Microbiota of food.....................................................630 26.8. Microbiota of industrial, domestic and medical facilities....................................631 26.9. Microbiological aspects of environmental protection....................................631 Chapter 27. Normal microbiota of the human body ..........................................633 (V. P. Shyrobokov, D. S. Yankovskyi, G. S. Dyment) 19 27.1. The importance of normal microbiota of the human body ...................................633 27.2. General ideas about the Human Microbial Ecology......................................634 27.3. Microbiota of the oral cavity.................................................636 27.4. Microbiota of esophagus....................................................636 27.5. Microbiota of the stomach.................................................636 27.6. Microbiota of small intestine................................................637 27.7. Microbiota of colon......................................................637 27.7.1. Anaerobic association .................................................639 27.7.2. Aerobic and facultative-anaerobic representatives of normal microbiota of colon ...................646 27.7.3. Transient microbiota ................................................648 27.8. Physiological functions of the normal microbiota of the digestive tract............................648 27.9. Skin microbiota........................................................649 27.10. Microbiota of the urogenital tract.............................................650 27.11. Microbiota of respiratory tract and conjunctiva.......................................651 27.12. Eubiosis and its disorders.................................................651 27.13. Means of bacterial prophylaxis and therapy........................................654 Chapter 28. Sanitary microbiology..................................................657 (O. V. Salata) 28.1. Sanitary-indicative microorganisms..............................................657 28.2. Microbiological air control .................................................658 28.3. Microbiological water control.................................................659 28.4. Microbiological soil control...................................................660 28.5. Microbiological control of household items...........................................661 28.6. Microbiological control of food.................................................662 28.7. Sanitary-virological research ................................................663 28.7.1. Sanitary virology of water and soil ...........................................663 28.7.2. Sanitary virology of air ................................................664 Chapter 29. Microbiota of the oral cavity ..............................................666 (V. V. Danyleichenko) 29.1. Normal microbiota of the oral cavity.............................................666 29.2. Local immunity of oral cavity .................................................668 29.3. Role of microorganisms in the formation and development of diseases of the maxillofacial region ................669 Chapter 30. Microbiological research in pharmacy.........................................672 30.1. Phytopathogenic bacteria (I. M. Fedechko)...........................................672 30.2. Phytopathogenic viruses (I. M. Fedechko)..........................................673 30.3. Phytopathogenic fungi (I. M. Fedechko)...........................................673 30.4. Manifestations of pathogenic effect of phytopathogenic microorganisms on plants (I. M. Fedechko) .............674 30.5. Diagnostics of infectious diseases in plants ...........................................675 30.6. Microbiological studies of medicinal raw materials, semi-finished products and finished dosage forms.............676 30.7. Microbiological drug control in pharmacy manufacture and pharmaceutical companies.....................677 Chapter 31. Instead of conclusion. Microbial history of the earth’s biosphere............................684 (A. Y. Tsyhanenko, V. P. Shyrobokov) 31.1. Evidence of microbial paleontology..............................................685 31.2. Hypotheses of the origin of life .................................................690 31.3. Role of clays in the evolution of life ...............................................692 Attachment. The main pathogenic bacteria, viruses, microscopic fungi, protozoa and the diseases they cause .........701 (S. I. Klymnyuk) Bibliography............................................................721 Subject index .............................................................723 Index of latin names of microorganisms and helminths ........................................735 Name index..............................................................739 Дод.точки доступу: Andrianova, T. V. Андріанова Тетяна Володимирівна Bobyr, V. V. Бобир Віталій Васильович Danyleichenko, V. V. Данилейченко Валерій Васильович Dyment, G. S. Dziublyk, I. V. Evtushenko, O. I. Fedechko, I. M. Furman, A. A. Klymnyuk, S. I. Koval, E. Z. at al. Shyrobokov, V. P. \ed.\ Широбоков В. П. Примірників всього: 192 ЧЗ (1), Наук.Аб. (5), Гурт.4 (2), Уч.Аб. (184) Вільні: ЧЗ (1), Наук.Аб. (5), Гурт.4 (2), Уч.Аб. (184) |
М 98 Murray, Patrick (Senior Worldwide Director, Scientific Affairs, BD Diagnostics Systems, Sparks, Maryland, Adjunct Professor, Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland). Basic medical microbiology / P. R. Murray. - Philadelphia, PA : Elsevier, 2018. - viii, 232 p. : color. il. - На англ. мові. - Referenc. at the end of the chapt. - Index: p. 225-232. - ISBN 978-0-323-47676-8 : 1 481.00 грн. Study smart with Student Consult Переклад назви: Основи медичної мікробіології [Книга з кодом інтернет-доступу] / П. Мюррей
Рубрики: МІКРОБІОЛОГІЯ(АНГЛ) МЕДИЦИНА(АНГЛ) ВІРУСОЛОГІЯ(АНГЛ) МІКОЛОГІЯ(АНГЛ) ПАРАЗИТОЛОГІЯ(АНГЛ) Анотація: Authored by the lead author of the bestselling Medical Microbiology and written in the same tradition, Basic Medical Microbiology was designed as a straight-forward, practical introduction to this difficult topic. It provides students with a firm foundation in the principles and applications of microbiology, serving as an effective prep tool for examinations and the transition into clinical application. Key Features Carefully curated contents focus on the most commonly observed and tested organisms and diseases. Differential diagnosis, organism classification overview, and a list of antimicrobials used to treat infections are provided in the introductory chapter of each organism section, reinforcing the clinical application and relevance. Organized by organism; focuses on the association between an organism and disease. Concise tables and high-quality illustrations offer visual guidance and an easy review of key material. Clinical cases reinforce the clinical significance of each organism. Includes multiple-choice questions to aid in self-assessment and examination preparation. Student Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. Table of Contents Section I. Introduction Chapter 1. Overview of Medical Microbiology Section I. Bacteria Chapter 2. Introduction of Bacteria Chapter 3. Aerobic Gram-Positive Cocci Chapter 4. Aerobic Gram-Positive Rods Chapter 5. Acid-Fast Bacteria Chapter 6. Aerobic Gram-Negative Cocci and Coccobacilli Chapter 7. Aerobic Fermentative Gram-Negative Rods Chapter 8. Aerobic Non-fermentative Gram-Negative Rods Chapter 9. Anaerobic Bacteria Chapter 10. Spiral Shaped Bacteria Chapter 11. Intracellular Bacteria Section II. Viruses Chapter 12. Introduction to Viruses Chapter 13. Human Immunodeficiency Viruses Chapter 14. Human Herpes Viruses Chapter 15. Respiratory Viruses Chapter 16. Hepatitis Viruses Chapter 17. Gastrointestinal Viruses Section III. Fungi Chapter 18. Introduction to Fungi Chapter 19. Cutaneous and Subcutaneous Fungi Chapter 20. Systemic Dimorphic Fungi Chapter 21. Opportunistic Fungi Section IV. Parasites Chapter 22. Introduction to Parasites Chapter 23. Protozoa Chapter 24. Nematodes Chapter 25. Trematodes Chapter 26. Cestodes Chapter 27. Arthropods Section V. Review Questions Примірників всього: 15 Наук.Аб. (14), Гурт.4 (1) Вільні: Наук.Аб. (14), Гурт.4 (1) |
М 42 Medical Microbiology : A Guide to Microbial Infections: Pathogenesis, Immunity, Laboratory Investigation and Control / edited by M. R. Barer, W. Irving, A. Swann, N. Perera. - 19th ed.International ed.Print+Electronic package. - Edinburg etc. : Elsevier, 2019 (China). - xvi, 743 p. : color. il. ; 25 cm. - Contributors: p. vii-xi. - На англ. мові. - Bibliogr. at the end of the chapt. - Index: p. 711-743. - ISBN 978-0-7020-7199-7 : 1 672.00 грн. Переклад назви: Медична мікробіологія: посібник по мікробних інфекціях : патогенез, імунітет, лабораторні дослідження і контроль / за ред. М. Барера та ін. [Книга з кодом інтернет-доступу]
Рубрики: МІКРОБІОЛОГІЯ(АНГЛ) МЕДИЦИНА(АНГЛ) ІНФЕКЦІЙНІ ХВОРОБИ(АНГЛ) ВІРУСОЛОГІЯ(АНГЛ) МІКОЛОГІЯ(АНГЛ) ІМУНОЛОГІЯ(АНГЛ) Анотація: Now in a fully revised and updated 19th edition, Medical Microbiology provides comprehensive coverage of infection from the microbial perspective, combining a clear introduction to key principles with a focus explicitly geared to modern clinical practice. It provides ideal coverage for medical and biomedical students - with ‘Key Points’ boxes throughout to highlight the essentials - and sufficient detail to also inform specialists in training. Building on the success of previous editions, updates in Medical Microbiology 19e include: New and expanded coverage of hot topics and emerging areas important to clinical practice, including: Genomics The Human Microbiome Direct acting antiviral agents for the treatment of HCV infection Molecular methods in diagnostic microbiology Antibiotic Stewardship A new and improved downloadable eBook (from studentconsult) - for anytime access to the complete contents plus BONUS interactive learning materials: Clinical cases - to introduce how patients with infections present and help relate key principles to practice MCQs for each chapter - to check understanding and aid exam preparation Table of Contents MEDICAL MICROBIOLOGY, EIGHTEENTH NINETEENTH EDITION Section 1: Microbial Biology 1. Microbiology and Medicine 2. Morphology and Nature of Micro-Organisms 3. Bacterial Identification and Systematics (Classification, Identification and Typing of Micro-organisms) 4. Bacterial Growth, Physiology and Death 5. Antimicrobial Agents and Antimicrobial Susceptibility Testing 6. Bacterial Genetics 7. Virus-Cell Interactions Section 2: Infection and Immunity 8. Innate and Adaptive Immunity 9. Immunity In Infection 10. Bacterial Pathogenicity 11. The Human Microbiome and the Natural History of Infection Section 3: Bacterial Pathogens and Associated Diseases 12. Staphylococcus 13. Streptococcus and Enterococcus 14. Coryneform Bacteria, Listeria and Erysipelothrix 15. Bacillus 16. Shigella and Escherichia 17. Salmonella 18. Klebsiella, Enterobacter, Proteus and Other Enterobacteria 19. Yersinia 20. Campylobacter and Helicobacter 21. Vibrio 22. Pseudomonads and Non-Fermenters 23. Haemophilus 24. Bordetella 25. Legionella 26. Neisseria and Moraxella 27. Mycobacterium 28. Other Actinobacteria 29. Clostridium 30. Non-Sporing Anaerobes 31. Brucella, Bartonella and Streptobacillus 32. Treponema And Borrelia 33. Leptospira: Leptospirosis; Weil's Disease 34. Chlamydia 35. Mycoplasmas 36. Rickettsia, Orientia, Ehrlichia, Anaplasma and Coxiella Section 4: Viral Pathogens and Associated Diseases 37. Adenoviruses 38. Herpesviruses 39. Poxviruses 40. Papillomaviruses 41. Polyomaviruses 42. Hepadnaviruses 43. Parvoviruses 44. Picornaviruses 45. Orthomyxoviruses 46. Paramyxoviruses 47. Arboviruses - Alphaviruses, Flaviviruses and Bunyaviruses 48. Hepaciviruses 49. Hepeviruses 50. Arenaviruses and Filoviruses 51. Reoviruses 52. Retroviruses 53. Caliciviruses and Astroviruses 54. Coronaviruses 55. Rhabdoviruses 56. Togaviruses 57. Prion Diseases Section 5: Fungal Pathogens, Parasitic Infections and Medical Entomology 58. Fungi 59. Protozoa 60. Helminths 61. Arthropods Section 6: Diagnosis, Treatment and Control of Infection 62. Infective Syndromes 63. Diagnostic Procedures 64. Molecular Methods in Diagnostic Microbiology 65. Management of Antimicrobial Chemotherapy 66. Epidemiology and Control of Community Infections 67. Hospital Infection 68. Immunization Дод.точки доступу: Barer, Michael R. (Professor of Clinical Microbiology Department of Infection, Immunity and Inflammation, University of Leicester Medical School, Leicester, United Kingdom) \ed.\ Irving, Will \ed.\ Swann, Andrew \ed.\ Perera, Nelum \ed.\ Примірників всього: 15 Наук.Аб. (14), Гурт.4 (1) Вільні: Наук.Аб. (14), Гурт.4 (1) |
М 98 Murray, Patrick (Senior Worldwide Director, Scientific Affairs, BD Diagnostics, Sparks, Maryland, Adjunct Professor, Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland). Medical Microbiology / P. R. Murray, K. S. Rosenthal, M. A. Pfaller. - 8th ed.Print & eBook. - Philadelphia, PA : Elsevier, 2016 (China). - x, 836 p. : color. il. ; 28 cm. - На англ. мові. - Bibliogr. at the end of the chapt. - Index: p. 806-836. - ISBN 978-0-323-29956-5 : 3 296.00 грн. Study smart with Student Consult Переклад назви: Медична мікробіологія [Книга з кодом інтернет-доступу] / П. Мюррей, К. Розенталь, М. Пфальєр
Рубрики: МІКРОБІОЛОГІЯ(АНГЛ) МЕДИЦИНА(АНГЛ) ВІРУСОЛОГІЯ(АНГЛ) ПАРАЗИТОЛОГІЯ(АНГЛ) МІКОЛОГІЯ(АНГЛ) ІМУНОЛОГІЯ(АНГЛ) Анотація: Description Turn to Medical Microbiology, 8th Edition for a thorough, clinically relevant understanding of microbes and their diseases. This succinct, easy-to-use text presents the fundamentals of microbiology and immunology in a clearly written, engaging manner—effectively preparing you for your courses, exams, and beyond. Key Features Coverage of basic principles, immunology, laboratory diagnosis, bacteriology, virology, mycology, and parasitology help you master the essentials. Review questions at the end of each chapter correlate basic science with clinical practice to help you understand the clinical relevance of the organisms examined. Clinical cases illustrate the epidemiology, diagnosis, and treatment of infectious diseases, reinforcing a clinical approach to learning. Full-color clinical photographs, images, and illustrations help you visualize the clinical presentations of infections. Summary tables and text boxes emphasizing essential concepts and learning issues optimize exam review. Additional images, 200 self-assessment questions, NEW animations, and more. Table of Contents SECTION 1 Introduction 1 Introduction to Medical Microbiology 2 Human Microbiome in Health and Disease 3 Sterilization, Disinfection, and Antisepsis SECTION 2 General Principles of Laboratory Diagnosis 4 Microscopy and In Vitro Culture 5 Molecular Diagnosis 6 Serologic Diagnosis SECTION 3 Basic Concepts in the Immune Response 7 Elements of Host Protective Responses 8 Innate Host Responses 9 Antigen-Specific Immune Responses 10 Immune Responses to Infectious Agents 11 Antimicrobial Vaccines SECTION 4 Bacteriology 12 Bacterial Classification, Structure, and Replication 13 Bacterial Metabolism and Genetics 14 Mechanisms of Bacterial Pathogenesis 15 Role of Bacteria in Disease 16 Laboratory Diagnosis of Bacterial Diseases 17 Antibacterial Agents 18 Staphylococcus and Related Gram-Positive Cocci 19 Streptococcus and Enterococcus 20 Bacillus 21 Listeria and Related Gram-Positive Bacteria 22 Mycobacterium and Related Acid-Fast Bacteria 23 Neisseria and Related Genera 24 Haemophilus and Related Bacteria 25 Enterobacteriaceae 26 Vibrio and Related Bacteria 27 Pseudomonas and Related Bacteria 28 Campylobacter and Helicobacter 29 Miscellaneous Gram-Negative Rods 30 Clostridium 31 Non–Spore-Forming Anaerobic Bacteria 32 Treponema, Borrelia, and Leptospira 33 Mycoplasma and Ureaplasma SECTION 1 Introduction 1 Introduction to Medical Microbiology 2 Human Microbiome in Health and Disease 3 Sterilization, Disinfection, and Antisepsis SECTION 2 General Principles of Laboratory Diagnosis 4 Microscopy and In Vitro Culture 5 Molecular Diagnosis 6 Serologic Diagnosis SECTION 3 Basic Concepts in the Immune Response 7 Elements of Host Protective Responses 8 Innate Host Responses 9 Antigen-Specific Immune Responses 10 Immune Responses to Infectious Agents 11 Antimicrobial Vaccines SECTION 4 Bacteriology 12 Bacterial Classification, Structure, and Replication 13 Bacterial Metabolism and Genetics 14 Mechanisms of Bacterial Pathogenesis 15 Role of Bacteria in Disease 16 Laboratory Diagnosis of Bacterial Diseases 17 Antibacterial Agents 18 Staphylococcus and Related Gram-Positive Cocci 19 Streptococcus and Enterococcus 20 Bacillus 21 Listeria and Related Gram-Positive Bacteria 22 Mycobacterium and Related Acid-Fast Bacteria 23 Neisseria and Related Genera 24 Haemophilus and Related Bacteria 25 Enterobacteriaceae 26 Vibrio and Related Bacteria 27 Pseudomonas and Related Bacteria 28 Campylobacter and Helicobacter 29 Miscellaneous Gram-Negative Rods 30 Clostridium 31 Non–Spore-Forming Anaerobic Bacteria 32 Treponema, Borrelia, and Leptospira 33 Mycoplasma and Ureaplasma 34 Rickettsia, Ehrlichia, and Related Bacteria 35 Chlamydia and Chlamydophila SECTION 5 Virology 36 Viral Classification, Structure, and Replication 37 Mechanisms of Viral Pathogenesis 38 Role of Viruses in Disease View less oplasma and Ureaplasma 34 Rickettsia, Ehrlichia, and Related Bacteria 35 Chlamydia and Chlamydophila SECTION 5 Virology 36 Viral Classification, Structure, and Replication 37 Mechanisms of Viral Pathogenesis 38 Role of Viruses in Disease 39 Laboratory Diagnosis of Viral Diseases 40 Antiviral Agents and Infection Control 41 Papillomaviruses and Polyomaviruses 42 Adenoviruses 43 Human Herpesviruses 44 Poxviruses 45 Parvoviruses 46 Picornaviruses 47 Coronaviruses and Noroviruses 48 Paramyxoviruses 49 Orthomyxoviruses 50 Rhabdoviruses, Filoviruses, and Bornaviruses 51 Reoviruses 52 Togaviruses and Flaviviruses 53 Bunyaviridae and Arenaviridae 54 Retroviruses 55 Hepatitis Viruses 56 Prion Diseases SECTION 6 Mycology 57 Fungal Classification, Structure, and Replication 58 Pathogenesis of Fungal Disease 59 Role of Fungi in Disease 60 Laboratory Diagnosis of Fungal Disease 61 Antifungal Agents 62 Superficial and Cutaneous Mycoses 63 Subcutaneous Mycoses 64 Systemic Mycoses Caused by Dimorphic Fungi 65 Opportunistic Mycoses 66 Fungal and Fungal-Like Infections of Unusual or Uncertain Etiology 67 Mycotoxins and Mycotoxicoses SECTION 7 Parasitology 68 Parasitic Classification, Structure, and Replication 69 Pathogenesis of Parasitic Diseases 70 Role of Parasites in Disease 71 Laboratory Diagnosis of Parasitic Disease 72 Antiparasitic Agents 73 Intestinal and Urogenital Protozoa 74 Blood and Tissue Protozoa 75 Nematodes 76 Trematodes 77 Cestodes 78 Arthropods Дод.точки доступу: Rosenthal, Ken S. Professor of Biomedical Sciences and Director Microbiology and Immunology, Roseman University of Health Sciences College of Medicine, Las Vegas, Nevada; Emeritus Professor, Northeastern Ohio Medical University, Rootstown, Ohio Pfaller, Michael A. (Chief Medical Officer, T2 Biosystems, Lexington, Massachusetts, Professor Emeritus, University of Iowa College of Medicine and College of Public Health, Iowa City, Iowa) Примірників всього: 15 Наук.Аб. (14), Гурт.4 (1) Вільні: Наук.Аб. (14), Гурт.4 (1) |
М 42 Mims' Medical Microbiology and Immunology / R. V. Goering, H. M. Dockrell, M. Zuckerman, P. L. Chiodini. - 6th ed.International ed.Print+Electronic package. - Edinburg ; London ; New York etc. : Elsevier, 2019 (China). - xvi, 552 p. : color. il. ; 28 cm. - На англ. мові. - Bibliography - list of useful websites: p. 529-530. -Index: p. 531-552. - ISBN 978-0-7020-7154-6. - ISBN 978-0-7020-7156-0 : 1 385.00 грн. Переклад назви: Медична мікробіологія і імунологія Мімса / Р. Герінг та ін. [Книга з кодом інтернет-доступу]
Рубрики: МІКРОБІОЛОГІЯ(АНГЛ) ІМУНОЛОГІЯ(АНГЛ) ВІРУСОЛОГІЯ(АНГЛ) ПАРАЗИТОЛОГІЯ(АНГЛ) Анотація: Learn all the microbiology and basic immunology concepts you need to know for your courses and exams. Now fully revised and updated, Mims’ clinically relevant, systems-based approach and abundant colour illustrations make this complex subject easy to understand and remember. View less Learn about infections in the context of major body systems and understand why these are environments in which microbes can establish themselves, flourish, and give rise to pathologic changes. This systems-based approach to microbiology employs integrated and case-based teaching that places the ‘bug parade’ into a clinical context. View less Effectively review for problem-based courses with the help of chapter introductions and ‘Lessons in Microbiology’ text boxes that highlight the clinical relevance of the material, offer easy access to key concepts, and provide valuable review tools. Approach microbiology by body system or by pathogen through the accompanying electronic ‘Pathogen Parade’ – a quickly searchable, cross-referenced glossary of viruses, bacteria and fungi A new electronic ‘Vaccine Parade’ offers quick-reference coverage of the most commonly used vaccines in current clinical practice Deepen your understanding of epidemiology and the important role it plays in providing evidence-based identification of key risk factors for disease and targets for preventative medicine. Grasp and retain vital concepts easily, with a user-friendly colour coded format, succinct text, key concept boxes, and dynamic illustrations. New and enhanced information reflects the growing importance of the human microbiota and latest molecular approaches Access the complete contents on the go via the accompanying interactive eBook, with a range of bonus materials to enhance learning and retention – includes self-assessment materials and clinical cases to check your understanding and aid exam preparation. Table of Contents SECTION 1 THE ADVERSARIES – PATHOGENS 1. Pathogens as parasites 2. The bacteria 3. The viruses 4. The fungi 5. The protozoa 6. The helminths 7. The arthropods 8. Prions 9. The host–parasite relationship SECTION 2 THE ADVERSARIES – HOST DEFENCES View less 10.The innate defences of the body 11. Adaptive immune responses bring specificity 12. Cooperation leads to effective immune responses SECTION 3 THE CONFLICTS View less 13. Background to the infectious diseases 14. Entry, exit and transmission 15. Immune defences in action 16. Spread and replication 17. Parasite survival strategies and persistent infections 18. Pathological consequences of infection SECTION 4 CLINICAL MANIFESTATION AND DIAGNOSIS OF INFECTIONS BY BODY SYSTEM View less The clinical manifestations of infection 19. Upper respiratory tract infections 20. Lower respiratory tract infections 21. Urinary tract infections 22. Sexually transmitted infections 23. Gastrointestinal tract infections 24. Obstetric and perinatal infections 25. Central nervous system infections 26. Infections of the eye 27. Infections of the skin, soft tissue, muscle and associated systems 28. Vector-borne infections 29. Multisystem zoonoses 30. Fever of unknown origin 31. Infections in the compromised host SECTION 5 DIAGNOSIS AND CONTROL View less 32. Diagnosis of infection and assessment of host defence mechanisms 33. Epidemiology and control of infectious diseases 34. Attacking the enemy: antimicrobial agents and chemotherapy 35. Protecting the host: vaccination 36. Active, passive and adoptive immunotherapy 37. Infection control Дод.точки доступу: Goering, Richard V. Dockrell, Hazel M. Zuckerman, Mark Chiodini, Peter L. Mims, Cedric A. Примірників всього: 15 Наук.Аб. (14), Гурт.4 (1) Вільні: Наук.Аб. (14), Гурт.4 (1) |
К 20 Cappuccino, James G. (SUNY, Rockland Community College). Microbiology : A Laboratory Manual / J. G. Cappuccino, C. Welsh. - 11th ed.Global ed. - Harlow, England ; London ; New York etc. : Pearson, 2018 (Malaysia). - 560 p. : color il. ; 28 cm. - На англ. мові. - Index: p. 549-560. - ISBN 978-0-134-09863-0 : 2 767.00 грн Переклад назви: Капучіно Дж., Велш Ч. Мікробіологія: Лабораторний посібник
Рубрики: МІКРОБІОЛОГІЯ(АНГЛ) ВІРУСОЛОГІЯ(АНГЛ) ІМУНОЛОГІЯ(АНГЛ) ПАРАЗИТОЛОГІЯ(АНГЛ) ДІАГНОСТИЧНІ МЕТОДИ ТА ПРОЦЕДУРИ(АНГЛ) Дод.точки доступу: Welsh, Chad T. (Lindenwood University) Примірників всього: 15 Наук.Аб. (14), Гурт.4 (1) Вільні: Наук.Аб. (14), Гурт.4 (1) |
М 42 Jawetz, Melnick & Adelberg's Medical Microbiology / K. C. Carroll, T. A. Mietzner, J. A. Hobden et al. - 27th ed.International ed. - New York ; Chicago ; San Francisco etc. : McGraw Hill Education, 2016 (China). - xii, 852 p. : color. il., il. ; 28 cm. - (A LANGE medical book). - На англ. мові. - Referenc. at the end of the chapt. - Index: p. 809-851. - ISBN 9780-0-71-82498-9 : 1 742.00 грн На обкл. авт.: Karen C. Carroll, Stephen A. Morse, Timothy A. Mietzner, Steve Miller Переклад назви: Медична мікробіологія Джавця, Мельника та Ейдельберга / К. Керрол та ін.
Рубрики: МІКРОБІОЛОГІЯ(АНГЛ) МЕДИЦИНА(АНГЛ) ІМУНОЛОГІЯ(АНГЛ) ВІРУСОЛОГІЯ(АНГЛ) ПАРАЗИТОЛОГІЯ(АНГЛ) Анотація: Contents Preface xii SECTION I FUNDAMENTALS OF MICROBIOLOGY 1 Stephen A. Morse, PhD and Timothy A. Meitzner, PhD 1. The Science of Microbiology 1 Introduction 1 Biologic Principles Illustrated by Microbiology 1 Viruses 2 Prions 3 Prokaryotes 4 Protists 7 Chapter Summary 9 Review Questions 9 2. Cell Structure 11 Optical Methods 11 Eukaryotic Cell Structure 13 Prokaryotic Cell Structure 15 Staining 38 Morphologic Changes During Growth 39 Chapter Summary 40 Review Questions 40 3. Classification of Bacteria 43 Taxonomy—The Vocabulary of Medical Microbiology 43 Criteria for Identification of Bacteria 43 Classification Systems 46 Description of the Major Categories and Groups of Bacteria 48 Nonculture Methods for the Identification of Pathogenic Microorganisms 52 Objectives 53 Review Questions 53 4. Growth, Survival, and Death of Microorganisms 55 Survival of Microorganisms in the Natural Environment 55 The Meaning of Growth 55 Exponential Growth 56 The Growth Curve in Batch Culture 57 Maintenance of Cells in the Exponential Phase 58 Growth in Biofilms 58 Definition and Measurement of Death 59 Environmental Control of Microbial Growth 59 Strategies to Control Bacteria at the Environmental Level 59 General Mechanisms of Biocide Action 60 Specific Actions of Selected Biocides 63 Relationship of Biocide Concentration and Time on Antimicrobial Killing 64 Summary 65 Key Concepts 65 Review Questions 66 5. Cultivation of Microorganisms 69 Requirements for Growth 69 Sources of Metabolic Energy 69 Nutrition 70 Environmental Factors Affecting Growth 71 Cultivation Methods 74 Chapter Summary 78 Review Questions 78 6. Microbial Metabolism 81 Role of Metabolism in Biosynthesis and Growth 81 Focal Metabolites and Their Interconversion 81 Assimilatory Pathways 84 Biosynthetic Pathways 92 Patterns of Microbial Energy-Yielding Metabolism 94 Regulation of Metabolic Pathways 101 Chapter Summary 103 Review Questions 103 7. Microbial Genetics 105 Nucleic Acids and Their Organization in Eukaryotic, Prokaryotic, and Viral Genomes 105 iii Caroll_FM_pi-xii.indd 3 5/30/15 2:18 PM iv Contents Replication 110 Transfer of DNA 111 Mutation and Gene Rearrangement 114 Gene Expression 115 Genetic Engineering 117 Characterization of Cloned DNA 120 Site-Directed Mutagenesis 123 Analysis With Cloned DNA: Hybridization Probes 124 Manipulation of Cloned DNA 124 Objectives 125 Review Questions 125 SECTION II IMMUNOLOGY 127 Barbara Detrick, PhD 8. Immunology 127 Overview 127 Innate Immunity 127 Adaptive Immunity 130 Complement 141 Cytokines 143 Hypersensitivity 145 Deficiencies of the Immune Response 146 Clinical Immunology Laboratory (Diagnostic Testing) 147 Chapter Summary 149 Review Questions 149 SECTION III BACTERIOLOGY 153 Karen C. Carroll, MD and Jeffery A. Hobden, PhD 9. Pathogenesis of Bacterial Infection 153 Identifying Bacteria That Cause Disease 154 Transmission of Infection 155 The Infectious Process 156 Genomics and Bacterial Pathogenicity 156 Regulation of Bacterial Virulence Factors 157 Bacterial Virulence Factors 158 Chapter Summary 165 Review Questions 165 10. Normal Human Microbiota 169 Human Microbiome Project 169 Role of the Resident Microbiota 169 Normal Microbiota of the Skin 171 Normal Microbiota of the Mouth and Upper Respiratory Tract 171 Normal Microbiota of the Urethra 176 Normal Microbiota of the Vagina 176 Normal Microbiota of the Conjunctiva 176 Chapter Summary 177 Review Questions 177 11. Spore-Forming Gram-Positive Bacilli: Bacillus and Clostridium Species 179 Bacillus Species 179 Bacillus anthracis 179 Bacillus cereus 182 Clostridium Species 182 Clostridium botulinum 183 Clostridium tetani 184 Clostridia That Produce Invasive Infections 186 Clostridium difficile and Diarrheal Disease 187 Review Questions 188 12. Aerobic Non–Spore-Forming Gram-Positive Bacilli: Corynebacterium, Listeria, Erysipelothrix, Nocardia, and Related Pathogens 191 Corynebacterium diphtheriae 192 Other Coryneform Bacteria 195 Listeria monocytogenes 196 Erysipelothrix rhusiopathiae 198 Complex Aerobic Actinomycetes 198 Nocardiosis 199 Actinomycetoma 200 Review Questions 200 13. The Staphylococci 203 Chapter Summary 210 Review Questions 210 14. The Streptococci, Enterococci, and Related Genera 213 Classification of Streptococci 213 Streptococci of Particular Medical Interest 215 Streptococcus pyogenes 215 Streptococcus agalactiae 220 Groups C and G 220 Group D Streptococci 221 Streptococcus anginosus Group 221 Groups E, F, G, H, and K–U Streptococci 221 Viridans Streptococci 221 Nutritionally Variant Streptococci 222 Peptostreptococcus and Related Genera 222 Streptococcus pneumoniae 222 Enterococci 226 Other Catalase-Negative Gram-Positive Cocci 227 Review Questions 228 Caroll_FM_pi-xii.indd 4 5/30/15 2:18 PM Contents v 15. Enteric Gram-Negative Rods (Enterobacteriaceae) 231 Classification 231 Diseases Caused By Enterobacteriaceae Other Than Salmonella and Shigella 234 The Shigellae 237 The Salmonellae 239 Chapter Summary 242 Review Questions 243 16. Pseudomonads and Acinetobacter 245 The Pseudomonad Group 245 Pseudomonas aeruginosa 245 Burkholderia pseudomallei 248 Burkholderia cepacia Complex 248 Stenotrophomonas maltophilia 249 Acinetobacter 249 Chapter Summary 249 Review Questions 249 17. Vibrio, Campylobacter, and Helicobacter 253 The Vibrios 253 Vibrio cholerae 253 Vibrio parahaemolyticus and Vibrio vulnificus 256 Campylobacter 256 Campylobacter jejuni 256 Helicobacter pylori 258 Review Questions 259 18. Haemophilus, Bordetella, Brucella, and Francisella 263 The Haemophilus Species 263 Haemophilus influenzae 263 Haemophilus aegyptius 265 Aggregatibacter aphrophilus 266 Haemophilus ducreyi 266 Other Haemophilus Species 266 The Bordetellae 266 Bordetella pertussis 266 Bordetella parapertussis 268 Bordetella bronchiseptica 268 The Brucellae 269 Francisella tularensis and Tularemia 271 Review Questions 273 19. Yersinia and Pasteurella 275 Yersinia pestis and Plague 275 Yersinia enterocolitica 277 Pasteurella multocida 278 Review Questions 278 20. The Neisseriae 281 Neisseria gonorrhoeae 281 Neisseria meningitidis 287 Other Neisseriae 288 Chapter Summary 289 Review Questions 289 21. Infections Caused by Anaerobic Bacteria 293 Physiology and Growth Conditions for Anaerobes 293 Anaerobic Bacteria Found in Human Infections 294 Bacteria That Cause Vaginosis 295 Gardnerella vaginalis 295 Pathogenesis of Anaerobic Infections 296 The Polymicrobial Nature of Anaerobic Infections 297 Diagnosis of Anaerobic Infections 297 Treatment of Anaerobic Infections 298 Chapter Summary 298 Review Questions 298 22. Legionella, Bartonella, and Unusual Bacterial Pathogens 301 Legionella pneumophila and Other Legionellae 301 Bartonella 304 Streptobacillus moniliformis 306 Whipple Disease 306 Review Questions 307 23. Mycobacteria 309 Mycobacterium tuberculosis 309 Other Mycobacteria 317 Mycobacterium leprae 319 Review Questions 320 24. Spirochetes and Other Spiral Microorganisms 323 Treponema pallidum and Syphilis 323 Borrelia 327 Borrelia Species and Relapsing Fever 327 Borrelia burgdorferi and Lyme Disease 328 Leptospira and Leptospirosis 330 Review Questions 332 25. Mycoplasmas and Cell Wall–Defective Bacteria 335 Mycoplasmas 335 Mycoplasma pneumoniae and Atypical Pneumonias 337 Mycoplasma hominis 338 Ureaplasma urealyticum 338 Mycoplasma genitalium 338 Chapter Summary 338 Review Questions 339 Caroll_FM_pi-xii.indd 5 5/30/15 2:18 PM vi Contents 26. Rickettsia and Related Genera 341 General 341 Rickettsia and Orientia 341 Ehrlichia and Anaplasma 345 Coxiella burnetii 346 Review Questions 348 27. Chlamydia spp. 351 Chlamydia trachomatis Ocular, Genital, and Respiratory Infections 354 Trachoma 354 Chlamydia trachomatis Genital Infections and Inclusion Conjunctivitis 355 Chlamydia trachomatis and Neonatal Pneumonia 356 Lymphogranuloma Venereum 356 Chlamydia pneumoniae and Respiratory Infections 357 Chlamydia psittaci and Psittacosis 358 Chapter Summary 360 Review Questions 360 28. Antimicrobial Chemotherapy 363 Mechanisms of Action of Antimicrobial Drugs 363 Selective Toxicity 363 Inhibition of Cell Wall Synthesis 363 Inhibition/Alteration of Cell Membrane Function 365 Inhibition of Protein Synthesis 366 Inhibition of Nucleic Acid Synthesis 367 Resistance to Antimicrobial Drugs 368 Origin of Drug Resistance 368 Cross-Resistance 369 Limitation of Drug Resistance 369 Clinical Implications of Drug Resistance 369 Antimicrobial Activity in Vitro 370 Factors Affecting Antimicrobial Activity 370 Measurement of Antimicrobial Activity 371 Antimicrobial Activity in Vivo 372 Drug–Pathogen Relationships 372 Host–Pathogen Relationships 373 Clinical Use of Antibiotics 373 Selection of Antibiotics 373 Dangers of Indiscriminate Use 374 Antimicrobial Drugs Used in Combination 374 Antimicrobial Chemoprophylaxis 375 Antimicrobial Drugs for Systemic Administration 377 Penicillins 377 Cephalosporins 383 Other β-Lactam Drugs 385 Tetracyclines 385 Glycylcyclines 386 Chloramphenicol 386 Macrolides 387 Clindamycin and Lincomycin 387 Glycopeptides, Lipopeptides, Lipoglycopeptides 388 Streptogramins 388 Oxazolidinones 389 Bacitracin 389 Polymyxins 389 Aminoglycosides 389 Quinolones 391 Sulfonamides and Trimethoprim 392 Other Drugs with Specialized Uses 392 Drugs Used Primarily To Treat Mycobacterial Infections 393 Review Questions 394 SECTION IV VIROLOGY 397 Steve Miller, MD, PhD 29. General Properties of Viruses 397 Terms and Definitions in Virology 397 Evolutionary Origin of Viruses 398 Classification of Viruses 398 Principles of Virus Structure 404 Chemical Composition of Viruses 405 Cultivation and Detection of Viruses 407 Purification and Identification of Viruses 408 Laboratory Safety 409 Reaction to Physical and Chemical Agents 409 Replication of Viruses: an Overview 410 Genetics of Animal Viruses 414 Natural History (Ecology) and Modes of Transmission of Viruses 416 Chapter Summary 418 Review Questions 418 30. Pathogenesis and Control of Viral Diseases 421 Principles of Viral Diseases 421 Pathogenesis of Viral Diseases 421 Prevention and Treatment of Viral Infections 433 Chapter Summary 438 Review Questions 438 Caroll_FM_pi-xii.indd 6 5/30/15 2:18 PM Contents vii 31. Parvoviruses 441 Properties of Parvoviruses 441 Parvovirus Infections in Humans 441 Chapter Summary 445 Review Questions 445 32. Adenoviruses 447 Properties of Adenoviruses 447 Adenovirus Infections in Humans 451 Chapter Summary 454 Review Questions 454 33. Herpesviruses 457 Properties of Herpesviruses 457 Herpesvirus Infections in Humans 460 Herpes Simplex Viruses 460 Varicella-Zoster Virus 466 Cytomegalovirus 470 Epstein-Barr Virus 474 Human Herpesvirus 6 477 Human Herpesvirus 7 478 Human Herpesvirus 8 478 Herpes B Virus 478 Chapter Summary 479 Review Questions 479 34. Poxviruses 483 Properties of Poxviruses 483 Poxvirus Infections in Humans: Vaccinia and Variola 486 Monkeypox Infections 490 Cowpox Infections 490 Buffalopox Infections 490 Orf Virus Infections 490 Molluscum Contagiosum 490 Tanapox and Yaba Monkey Tumor Poxvirus Infections 492 Chapter Summary 493 Review Questions 493 35. Hepatitis Viruses 495 Properties of Hepatitis Viruses 495 Hepatitis Virus Infections in Humans 500 Chapter Summary 512 Review Questions 512 36. Picornaviruses (Enterovirus and Rhinovirus Groups) 515 Properties of Picornaviruses 515 Enterovirus Group 516 Polioviruses 516 Coxsackieviruses 522 Other Enteroviruses 524 Enteroviruses in the Environment 525 Rhinoviruses 526 Parechovirus Group 527 Foot-and-Mouth Disease (Aphthovirus of Cattle) 528 Chapter Summary 528 Review Questions 528 37. Reoviruses, Rotaviruses, and Caliciviruses 531 Reoviruses and Rotaviruses 531 Rotaviruses 532 Reoviruses 536 Orbiviruses and Coltiviruses 536 Caliciviruses 536 Astroviruses 539 Chapter Summary 539 Review Questions 539 38. Arthropod-Borne and Rodent-Borne Viral Diseases 541 Human Arbovirus Infections 541 Togavirus and Flavivirus Encephalitis 543 Yellow Fever Virus 550 Dengue Virus 552 Bunyavirus Encephalitis Viruses 554 Sandfly Fever Virus 554 Rift Valley Fever Virus 554 Severe Fever with Thrombocytopenia Syndrome Virus 555 Heartland Virus 555 Colorado Tick Fever Virus 555 Rodent-Borne Hemorrhagic Fevers 555 Bunyavirus Diseases 555 Arenavirus Diseases 557 Filovirus Diseases 559 Chapter Summary 561 Review Questions 561 39. Orthomyxoviruses (Influenza Viruses) 565 Properties of Orthomyxoviruses 565 Influenza Virus Infections in Humans 570 Chapter Summary 576 Review Questions 576 40. Paramyxoviruses and Rubella Virus 579 Properties of Paramyxoviruses 579 Parainfluenza Virus Infections 583 Respiratory Syncytial Virus Infections 586 Human Metapneumovirus Infections 588 Mumps Virus Infections 589 Measles (Rubeola) Virus Infections 591 Hendra Virus and Nipah Virus Infections 594 Rubella (German Measles) Virus Infections 595 Caroll_FM_pi-xii.indd 7 5/30/15 2:18 PM viii Contents Postnatal Rubella 595 Congenital Rubella Syndrome 596 Chapter Summary 597 Review Questions 598 41. Coronaviruses 601 Properties of Coronaviruses 601 Coronavirus Infections in Humans 602 Chapter Summary 605 Review Questions 605 42. Rabies, Slow Virus Infections, and Prion Diseases 607 Rabies 607 Borna Disease 613 Slow Virus Infections and Prion Diseases 613 Chapter Summary 616 Review Questions 616 43. Human Cancer Viruses 619 General Features of Viral Carcinogenesis 619 Molecular Mechanisms of Carcinogensis 620 Interactions of Tumor Viruses with Their Hosts 621 RNA Tumor Viruses 622 Hepatitis C Virus 622 Retroviruses 622 DNA Tumor Viruses 628 Polyomaviruses 628 Papillomaviruses 630 Adenoviruses 633 Herpesviruses 633 Poxviruses 634 Hepatitis B Virus 634 How to Prove That a Virus Causes Human Cancer 635 Chapter Summary 635 Review Questions 635 44. Aids and Lentiviruses 639 Properties of Lentiviruses 639 Hiv Infections in Humans 643 Chapter Summary 653 Review Questions 653 SECTION V MYCOLOGY 657 Thomas G. Mitchell, PhD 45. Medical Mycology 657 General Properties, Virulence, and Classification of Pathogenic Fungi 658 Laboratory Diagnosis of Mycoses 663 Superficial Mycoses 665 Cutaneous Mycoses 665 Key Concepts: Superficial and Cutaneous Mycoses 669 Subcutaneous Mycoses 669 Sporotrichosis 670 Chromoblastomycosis 671 Phaeohyphomycosis 672 Mycetoma 673 Key Concepts: Subcutaneous Mycoses 674 Endemic Mycoses 674 Coccidioidomycosis 675 Histoplasmosis 678 Blastomycosis 681 Paracoccidioidomycosis 682 Key Concepts: Endemic Mycoses 683 Opportunistic Mycoses 683 Candidiasis 684 Cryptococcosis 687 Aspergillosis 690 Mucormycosis 691 Pneumocystis Pneumonia 691 Penicilliosis 692 Other Opportunistic Mycoses 693 Key Concepts: Opportunistic Mycoses 693 Antifungal Prophylaxis 693 Hypersensitivity to Fungi 694 Mycotoxins 694 Antifungal Chemotherapy 694 Topical Antifungal Agents 700 Key Concepts: Antifungal Chemotherapy 700 Review Questions 700 SECTION VI PARASITOLOGY 705 Judy A. Sakanari, PhD and James H. McKerrow, MD, PhD 46. Medical Parasitology 705 Classification of Parasites 705 Intestinal Protozoan Infections 709 Giardia lamblia (Intestinal Flagellate) 709 Entamoeba histolytica (Intestinal and Tissue Ameba) 710 Other Intestinal Amebae 712 Cryptosporidium (Intestinal Sporozoa) 712 Cyclospora (Intestinal Sporozoa) 713 Sexually Transmitted Protozoan Infection 713 Trichomonas vaginalis (Genitourinary Flagellate) 713 Blood and Tissue Protozoan Infections 713 Blood Flagellates 713 Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense (Blood Flagellates) 714 Trypanosoma cruzi (Blood Flagellate) 715 Leishmania Species (Blood Flagellates) 715 Entamoeba histolytica (Tissue Ameba)—See Intestinal Protozoan Infections Section 717 Naegleria fowleri, Acanthamoeba castellanii, and Balamuthia mandrillaris (Free-Living Amebae) 717 Plasmodium Species (Blood Sporozoa) 717 Babesia microti (Blood Sporozoa) 721 Toxoplasma gondii (Tissue Sporozoa) 722 Microsporidia 722 Intestinal Helminthic Infections 723 Enterobius vermicularis (Pinworm—Intestinal Nematode) 723 Trichuris trichiura (Whipworm—Intestinal Nematode) 724 Ascaris lumbricoides (Human Roundworm— Intestinal Nematode) 724 Ancylostoma duodenale and Necator americanus (Human Hookworms—Intestinal Nematode) 728 Strongyloides stercoralis (Human Threadworm— Intestinal and Tissue Nematode) 729 Trichinella spiralis (Intestinal and Tissue Nematode) 730 Fasciolopsis buski (Giant Intestinal Fluke—Intestinal Trematode) 730 Taenia saginata (Beef Tapeworm—Intestinal Cestode) and Taenia solium (Pork Tapeworm— Intestinal and Tissue Cestode) 731 Diphyllobothrium latum (Broad Fish Tapeworm— Intestinal Cestode) 731 Hymenolepis nana (Dwarf Tapeworm—Intestinal Cestode) 732 Dipylidium caninum (Dog Tapeworm—Intestinal Cestode) 732 Blood and Tissue Helminthic Infections 732 Wuchereria bancrofti, brugia malayi, and Brugia timori (Lymphatic Filariasis—Tissue Nematodes) 732 Onchocerca volvulus (River Blindness—Tissue Nematode) 733 Dracunculus medinensis (Guinea Worm—Tissue Nematode) 734 Larva Migrans (Zoonotic Larval Nematode Infections) 734 Clonorchis sinensis (Chinese Liver Fluke), Fasciola hepatica (Sheep Liver Fluke), and Paragonimus westermani (Lung Fluke)—Tissue Trematodes 734 Schistosoma mansoni, Schistosoma japonicum, and Schistosoma haematobium (Blood Flukes) 735 Tissue Cestode Infections (Caused By the Larval Stages) 736 Taenia solium—Cysticercosis/ Neurocysticercosis 736 Echinococcus granulosus (Hydatid Cyst) 736 Review Questions 737 SECTION VII DIAGNOSTIC MEDICAL MICROBIOLOGY AND CLINICAL CORRELATION 741 Karen C. Carroll, MD and Steve Miller, MD, PhD 47. Principles of Diagnostic Medical Microbiology 741 Communication Between Physician and Laboratory 741 Diagnosis of Bacterial and Fungal Infections 742 The Importance of Normal Bacteria l and Fungal Microbiota 753 Laboratory Aids in the Selection of Antimicrobial Therapy 754 Diagnosis of Infection By Anatomic Site 755 Anaerobic Infections 761 Diagnosis of Chlamydial Infections 761 Diagnosis of Viral Infections 762 Review Questions 769 48. Cases and Clinical Correlations 773 Central Nervous System 773 Respiratory 777 Heart 782 Abdomen 783 Urinary Tract 785 Bone and Soft Tissue 790 Sexually Transmitted Diseases 792 Mycobacterium tuberculosis Infections 795 Myocobacterium avium Complex 798 Infections in Transplant Patients 799 Emerging Infections 805 Index 809 Blood and Tissue Protozoan Infections 713 Blood Flagellates 713 Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense (Blood Flagellates) 714 Trypanosoma cruzi (Blood Flagellate) 715 Leishmania Species (Blood Flagellates) 715 Entamoeba histolytica (Tissue Ameba)—See Intestinal Protozoan Infections Section 717 Naegleria fowleri, Acanthamoeba castellanii, and Balamuthia mandrillaris (Free-Living Amebae) 717 Plasmodium Species (Blood Sporozoa) 717 Babesia microti (Blood Sporozoa) 721 Toxoplasma gondii (Tissue Sporozoa) 722 Microsporidia 722 Intestinal Helminthic Infections 723 Enterobius vermicularis (Pinworm—Intestinal Nematode) 723 Trichuris trichiura (Whipworm—Intestinal Nematode) 724 Ascaris lumbricoides (Human Roundworm— Intestinal Nematode) 724 Ancylostoma duodenale and Necator americanus (Human Hookworms—Intestinal Nematode) 728 Strongyloides stercoralis (Human Threadworm— Intestinal and Tissue Nematode) 729 Trichinella spiralis (Intestinal and Tissue Nematode) 730 Fasciolopsis buski (Giant Intestinal Fluke—Intestinal Trematode) 730 Taenia saginata (Beef Tapeworm—Intestinal Cestode) and Taenia solium (Pork Tapeworm— Intestinal and Tissue Cestode) 731 Diphyllobothrium latum (Broad Fish Tapeworm— Intestinal Cestode) 731 Hymenolepis nana (Dwarf Tapeworm—Intestinal Cestode) 732 Dipylidium caninum (Dog Tapeworm—Intestinal Cestode) 732 Blood and Tissue Helminthic Infections 732 Wuchereria bancrofti, brugia malayi, and Brugia timori (Lymphatic Filariasis—Tissue Nematodes) 732 Onchocerca volvulus (River Blindness—Tissue Nematode) 733 Dracunculus medinensis (Guinea Worm—Tissue Nematode) 734 Larva Migrans (Zoonotic Larval Nematode Infections) 734 Перейти к внешнему ресурсу http://med-mu.com/wp-content/uploads/2018/06/Jawetz-Melnick-Adelbergs-Medical-Microbiology-27-edition.pdf, Перейти к внешнему ресурсу БД Книги. № 33392, 36842, 33510 Дод.точки доступу: Carroll, Karen C. (Professor of Pathology The Johns Hopkins University School of Medicine Director, Division Medical Microbiology The Johns Medical Institutions Baltimore, Maryland) Mietzner, Timothy A. (PhD) Hobden, Jeffery A. Hobden (PhD) Detrick, Barbara (PhD) Miller, Steve (MD, PhD) Mitchell, Thomas G. (PhD) Morse, Stephen A. McKerrow, James H. (MD, PhD) Sakanari, Judy A. (PhD) Примірників всього: 15 ЧЗ (1), Наук.Аб. (13), Гурт.4 (1) Вільні: ЧЗ (1), Наук.Аб. (13), Гурт.4 (1) |