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   577.1
   Б 63


    Biological and bioorganic chemistry. In 2 books : [textbook for students of higher medical educational establishments]. Book 2. Biological chemistry / ed. Yu. I. Gubsky, I. V. Nizhenkovska ; Yu. I. Gubsky, I. V. Nizhenkovska, M. M. Korda et al. - 2nd ed. - K. : Medicine Publishing, 2021. - 542 p. : il. - На англ. мові. - Index: p. 535-541. - References: p. 542. - ISBN 978-617-505-886-2 : 360.00 грн.
Переклад назви: Біологічна та біоорганічна хімія. В 2-х кн. Кн. 2. Біологічна хімія: підручник / за ред. Ю. Губського, І. Ніженковської

УДК

577.1(075.8)

Рубрики: БІОХІМІЯ(АНГЛ)--Підручник

Кл.слова (ненормовані):
national textbook -- підручники англійською
Анотація: This textbook contains a systematic presentation of the course of biological chemistry according to the educational program for students of higher medical (pharmaceutical) educational establishments. The core text of this book examines the structure of an enzyme, and the metabolic pathways of the major classes of biomolecules (proteins, amino acids, carbohydrates, lipids, nucleotides, porphyrins); structural features and properties of nucleic acids, DNA and RNA; molecular biology and genetics, biochemical foundations of the physiological functions of the human body and their neurohumoral regulation are highlighted. Considerable attention is paid to the molecular mechanisms underlying the functions of blood cells, liver, kidneys, muscles, connective tissue, immune and nervous systems. The biochemical basis of the pathogenesis of atherosclerosis, diabetes mellitus, obesity, diseases of the endocrine, immune, nervous systems and connective tissue are considered. In addition to informational material, each chapter of the textbook contains tests and tasks for self-control. Introduction. History of development of biochemistry PART I. GENERAL PRINCIPLES OF REGULATION OF METABOLISM Chapter 1. Biomolecules and cellular structures 1.1. Chemical composition of living organism 1.2. Biomolecules and their functions 1.3. Scheme of structure of prokaryotic and eukaryotic cells 1.4. Biological membranes Chapter 2. Enzymes 2.1. Enzymes: structure, properties and classification 2.2. Mechanism of the enzyme action 2.3. Kinetics of enzymatic reactions. The units of enzymatic activity 2.4. Regulation of enzymatic processes 2.5. Medical enzymology 2.6. Cofactors and coenzymes: chemical structure and functions Chapter 3. Fundamental regularities of metabolism. Tricarboxylic acid cycle 3.1. Common pathways of protein, lipid, and carbohydrate metabolism 3.2. Oxidative decarboxylation of pyruvic acid 3.3. Tricarboxylic acid cycle or Krebs cycle Chapter 4. Molecular foundations of bioenergetics 4.1. Pathways of the oxygen consumption in the reactions of biological oxidation 4.2. Tissue respiration 4.3. Chemiosmotic mechanism of ATP synthesis in mitochondria 4.4. Non-phosphorylative oxidation in electron trasport chain as the mechanism of heat production in the mitochondria 4.5. Inhibitors and uncouplers of oxidative phosphorylation Chapter 5. Hormonal regulation of metabolism 5.1. General characteristics of hormones 5.2. Classification of hormones 5.3. Mechanism of action of hydrophilic hormones 5.4. Mechanism of action of hormones that interact with the intracellular receptors 5.5. Regulation of secretion of hormones PART II. CARBOHYDRATE, LIPID AND AMINO ACID METABOLISM. REGULATION OF CARBOHYDRATE, LIPID AND AMINO ACID METABOLISM Chapter 6. Carbohydrate metabolism. Regulation of carbohydrate metabolism 6.1. Glycolysis 6.2. Alcohol fermentation 6.3. Pentose phosphate pathway of glucose metabolism 6.4. Metabolism of fructose 6.5. Metabolism of sorbitol 6.6. Metabolism of galactose 6.7. Gluconeogenesis 6.8. Metabolism of glycogen 6.9. Regulation of glycogenolysis and glycogenesis Chapter 7. Lipid metabolism. Regulation of lipid metabolism 7.1. Metabolism of triacylglycerols 7.2. Metabolism of fatty acids 7.3. Metabolism of glycerol 7.4. Ketone body formation and utilization in normal and pathological conditions 7.5. Metabolism of phospholipids 7.6. Metabolism of cholesterol 7.7. Disorders of lipid metabolism Chapter 8. Amino acid metabolism. Enzymopathies of amino acid metabolism 8.1. General pathways of amino acids transformation 8.2. Formation and detoxification of ammonia. Urea cycle 8.3. Specialized pathways of acyclic and cyclic amino acids 8.4. Biosynthesis of porphyrins 8.5. Hereditary disorder of porphyrin metabolism PART III. MOLECULAR BIOLOGY. BIOCHEMISTRY OF INTERCELLULAR COMMUNICATIONS Chapter 9. Metabolism of nucleotides 9.1. Biosynthesis and catabolism of purine and pyrimidine nucleotides 9.2. Disorders of purine and pyrimidine metabolism Chapter 10. Fundamentals of molecular biology 10.1. Structure of deoxyribonucleic acid 10.2. Biosynthesis of deoxyribonucleic acid 10.3. Biosynthesis of ribonucleic acid (RNA) 10.4. Ribosomal protein syntesis (translation) 10.5. Antibiotics are inhibitors of template synthesis 10.6. Viruses and toxins are inhibitors of template synthesis in eukaryotic cells 10.7. Biochemical mechanism of antiviral effect of interferons Chapter 11. Fundamentals of molecular genetics 11.1. Phases of eukaryotic cell cycle. Biochemical mechanism of control of cell entry into mitosis 11.2. Molecular mechanism of mutations 11.3. Genetic recombinations 11.4. Amplification of genes (genes of metallothionein, dihydrofolate reductase) 11.5. Genetic engineering: some basic concepts, biomedical significance Chapter 12. Biochemistry of hormonal regulation 12.1. Hormones of hypotalamic-pituitary system 12.2. Pancreatic hormones 12.3. Hormones of digestive system 12.4. Hormones of thyroid gland 12.5. Hormonal regulation of calcium homeostasis 12.6. Steroid hormones of adrenal glands and gonads 12.7. Biological active eicosanoids 12.8. Eicosanoids in the inflammation Part IV. FUNCTIONAL BIOCHEMISTRY Chapter 13. Biochemystry of human nutrition 13.1. Macronutrients 13.2. Biochemical role of microelements 13.3. Digestion of nutrients in the digestive tract 13.4. Violations of digestion in alimentary canal 13.5. Vitamins Chapter 14. Biochemistry of blood 14.1. Respiratory function of red blood cells 14.2. Normal and pathological forms of hemoglobin 14.3. Acid-base balance and buffer systems of blood 14.4. Non-protein components of plasma 14.5. Blood proteins 14.6. Blood plasma lipoproteins 14.7. Blood coagulation, anticoagulant and fibrinolytic systems Chapter 15. Biochemistry of immune processes 15.1. Immunoglobulins: structure, biological functions 15.2. Mediators and hormones of immune system 15.3. Biochemical components of human complement system 15.4. Biochemical mechanisms of development of immunodeficiency Chapter 16. Biochemical functions of the liver 16.1. Bile formation in liver 16.2. Metabolism of bile pigments in the liver 16.3. Pathobiochemistry ofjaundice 16.4. Biochemical disturbances in certain liver diseases 16.5. Biotransformation of xenobiotics and endogenous toxins Chapter 17. Biochemical functions of the kidneys 17.1. Steps of urine formation 17.2. Physical characteristics of urine 17.3. Chemical composition of urine 17.4. Role of the kidneys in acid-base balance 17.5. Features of kidney metabolism 17.6. Biochemical tests of kidney function Chapter 18. Biochemistry of muscles 18.1. Structure of myofibrils 18.2. Chemical composition of muscle tissue 18.3. Biochemical features of cardiac and smooth muscles 18.4. Biochemical mechanisms of contraction and relaxation of muscles 18.5. Sources of energy for muscle constractions 18.6. Biochemical changes in muscle pathology Chapter 19. Biochemistry of connective tissue 19.1. Structure and metabolism of collagen 19.2. Elastin structure 19.3. Structure and metabolism of proteoglycans 19.4. Structure of glycoproteins Chapter 20. Biochemistry of nervous system 20.1. Chemical composition of the nervous system 20.2. Nervous tissue metabolism 20.3. Molecular basis of bioelectrical processes on the membrane of neurons 20.4. Neurotransmitters 20.5. Metabolism of neurotransmitters and neuromodulators in mental disorders 20.6. Neurochemical mechanisms of psychotropic drugs Answers for tests for self-control Index References
Дод.точки доступу:
Gubsky, Yuriy I.
Губський Юрій Іванович
Nizhenkovska, Iryna Volodymyrivna
Ніженковська Ірина Володимирівна
Korda, Mykhaylo Mykhaylovych
Корда Михайло Михайлович
Borzenko, B. G.
Brazaluk, O. Z.
Ersteniuk, G. M.
Efetov, K. O.
Zhukov, V. I.
Zaichko, N. V.
Komarevtseva, I. O.
Lutsyuk, M. B.
Neporada, K. S.
Непорада Каріне Степанівна
Tarasenko, L. M.
Тарасенко Лідія Максимівна et al.
Gubsky, Yuriy I. \ed.\
Nizhenkovska, Iryna Volodymyrivna \ed.\

Примірників всього: 2
Наук.Аб. (2)
Вільні: Наук.Аб. (2)

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   577.1
   Г 93

    Gubsky, Yuriy I..
    Bioorganic Chemistry : textbook for the students of medical universities [of the IVth level of accreditation with English as language of instruction] / Yu. Gubsky = Біоорганічна хімія : підручник для студентів мед. університетів / Ю. І. Губський. - 2nd ed.=2-ге вид. - Vinnytsya=Вінниця : Nova knyha=Нова Книга, 2019. - 223 p. - На англ. мові. - Suggested readigs: с. 218. - Index: с. 218-223. - ISBN 978-966-382-777-3 : 285.00 грн

УДК

577.1(075.8)

Рубрики: БІООРГАНІЧНА ХІМІЯ(АНГЛ)--Підручник

Кл.слова (ненормовані):
підручники
Дод.точки доступу:
Губський, Юрій Іванович

Примірників всього: 145
ЧЗ (1), Наук.Аб. (3), Гурт.4 (1), Уч.Аб. (139), ННА (1)
Вільні: ЧЗ (1), Наук.Аб. (3), Гурт.4 (1), Уч.Аб. (139), ННА (1)

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   577.1
   Г 93

    Gubsky, Yuriy I..
    Biological chemistry : [textbook for students of medical and pharmaceutical faculties of higher educational establishments of Ukraine] / Yu. Gubsky. - 2nd ed. - Vinnytsia : Nova Knyha, 2018. - 487 p. : il. - На англ. мові. - List references: p. 487. - ISBN 978-966-382-697-4 : 220.00 грн, 320.00 грн
Переклад назви: Біологічна хімія: підручник / Ю. Губський

ДРНТІ	76.03.31
УДК	577.1+612.015](075.8)

Рубрики: БИОХИМИЯ(англ)--підручник(англ)

МЕДИЦИНА

Кл.слова (ненормовані):
підручники(англ)
Анотація: Підручник з біологічної хімії складається з 30 розділів і містить текстові матеріали та велику кількість ілюстрацій, у тому числі хімічні формули, реакції та їх рівняння, рисунки складених внутрішньоклітинних перетворень біомолекул і метаболічні “схеми”. Підручник призначений для студентів медичних та фармацевтичних факультетів вищих навчальних закладів України.CONTENTS PREFACE ................. 10 Part 1. BIOMOLECULES. CELLS. METABOLISM Chapter 1. BIOCHEMISTRY: BIOMOLECULES, METABOLISM.... 13 1.1. Biochemistry as fundamental biomedical science........ 13 1.2. Biomolecules - major classes, representatives....... 14 Chapter 2. PROTEINS. AMINO ACIDS. PEPTIDES........ 19 2.1. Amino acids: structure, properties........... 19 2.2. Peptide bonds, polypeptides............ 24 2.3. Proteins. Levels of protein structure.........28 Chapter 3. NUCLEIC ACIDS. NUCLEOTIDES. DNA. RNA ....... .36 3.1. Nucleic acids and the flow of genetic information .......36 3.2. Nucleotides: structure, biological functions......... 37 3.3. Nucleic acids as polynucleotides: DNA, RNA ........42 Chapter 4. CARBOHYDRATES. SUGARS AND THEIR DERIVATIVES...46 4.1. Monosaccharides. Hexoses. Pentoses. Amino sugars ....... 47 4.2. Oligosaccharides. Homopolysaccharides ........49 4.3. Heteropolysaccharides. Glycoproteins .......... 53 Chapter 5. LIPIDS. FATTY ACIDS. BIOMEMBRANES ........ 57 5.1. General characteristics of lipids. Biological functions ....... 57 5.2. Fatty acids: structure and properties ........58 5.3. Structure and properties of special classes of lipids ..... 61 5.4. Steroids: cholesterol, bile acids, steroid hormones ... .. 67 Chapter 6. CELLS. METABOLISM: GENERAL ASPECTS ...... 71 6.1. Metabolism: overall conception, metabolic pathways ....... 71 6.2. Cells. Compartmentalization of metabolic pathways..... 72 Part 2. ENZYMES. GENERAL METABOLIC PATHWAYS Chapter 7. METABOLISM. ENZYMATIC REACTIONS ........ 777.1. Metabolism: general conceptions, metabolic pathways...... 77 7.2. Enzymes as the principal molecular devices of metabolism .....80 7.3. Enzyme nomenclature and classification........84 7.4. Molecular mechanisms of enzyme catalysis ........ 91 Chapter 8. COENZYMES. CONTROL OF ENZYMATIC REACTIONS ..... .94 8.1. Coenzymes: classification, structure. Vitamins as coenzyme precursors ... .94 8.2. Kinetics of enzyme catalysis. Michaelis - Menten theory....99 8.3. Inhibition of enzymes. Kinds of inhibitors ..... 103 8.4. Enzymic catalysis regulatory mechanisms ......... 107 Chapter 9. BIOENERGETICS-1. CATABOLIC PATHWAYS.TRICARBOXYLIC ACID CYCLE................ 114 9.1. Bioenergetics. ATP and other high-energy compounds ..... 114 9.2. Overview of catabolic pathway steps.......... 116 9.3. Tricarboxylic acid cycle: overview .......... 117 9.4. Tricarboxylic acid cycle: reactions and enzymes ....... 118 Chapter 10. BIOENERGETICS-2. MITOCHONDRIAL ELECTRON TRANSPORT. OXIDATIVE PHOSPHORYLATION ........... 124 10.1. General notions of free energy transfer in biochemical systems ... 124 10.2. Electron transport chain in mitochondria......... 126 10.3. Oxidative phosphorylation. ATP synthase ........ 131 Part 3. METABOLISM OF MAJOR CLASSES OF BIOMOLECULES Chapter 11. CARBOHYDRATE METABOLISM-1. PATHWAYS OF GLUCOSE OXIDATION ................ 137 11.1. Major routes of carbohydrate metabolism......... 137 11.2. Aerobic and anaerobic oxidation of glucose. Glycolysis. ...... 159 11.3. Enzymatic reactions of glycolysis. Regulation of glycolysis .... 140 11.4. Aerobic oxidation of glucose. Oxidative decarboxylation of pyruvate.. 149 11.5. Pentose phosphate pathway .......... 150 Chapter 12. CARBOHYDRATE METABOLISM-2. GLYCOGEN METABOLISM. GLUCONEOGENESIS............ 156 12.1. Glycogen metabolism. Glycogen-storage diseases ..... 156 12.2. Gluconeogenesis: reactions, regulation........ 167 12.3. Regulation of carbohydrate metabolism ....... 172 12.4. Control of blood plasma glucose. Diabetes mellitus....... 174 Chapter 13. LIPID METABOLISM-1. TRIACYLGLYCEROL CATABOLISM. OXIDATION OF FATTY ACIDS. KETOGENESIS ....... 177 13.1. Lipids: general characteristics, biological functions ....... 177 13.2. Fat metabolism: overview, lipolysis ........ 179 13.3. Degradation of fatty acids (rj-oxidation)....... 182 13.4. Ketone bodies. Ketogenesis in diabetes mellitus ...... 188 Chapter 14. LIPID METABOLISM-2. LIPOGENESIS. CHOLESTEROL METABOLISM. LIPID METABOLISM PATHOLOGY ...... 193 14.1. Biosynthesis of fatty acids: reactions, enzymes ....... 193 14.2. Biosynthesis of acylglycerols: triglycerides, phosphoglycerides.... 197 14.3. Sphingolipids: representatives, metabolism ....... 201 14.4. Cholesterol synthesis and biotransformation. Atherosclerosis ....207 Chapter 15. AMINO ACID METABOLISM-1. AMINO ACID DEGRADATION: DEAMINATION, TRANSAMINATION, DECARBOXYLATION. UREA CYCLE ... 213 15.1. Protein turnover. Principal pathways of amino acid metabolism ... 213 15.2. Transamination of amino acids: reactions, enzymes....... 216 15.3. Deamination of amino acids: reactions, enzymes......220 15.4. Decarboxylation of amino acids: reactions, biological significance.... 221 15.5. Amino nitrogen metabolism. Urea cycle: reactions, enzymes... 223 Chapter 16. AMINO ACID METABOLISM-2. AMINO ACID SPECIALIZED METABOLIC PATHWAYS. PORPHYRIN METABOLISM ...... .228 16.1. General pathways of amino acids carbon skeleton degradation ...228 16.2. Specialized pathways of individual amino acid metabolism ... 231 16.3. Amino acids as precursors of biologically important compounds ..242 16.4. Diseases associated with abnormal amino acid metabolism...244 16.5. Biosynthesis and catabolism of porphyrins. Gout.....245 Chapter 17. METABOLISM OF PURINE AND PYRIMIDINE NUCLEOTIDES. PURINE DEGRADATION. GOUT ........ 255 17.1. Nucleotides: structure, biochemical functions ........ 255 17.2. Biosynthesis of purine nucleotides ........ 257 17.3. Biosynthesis of pyrimidine nucleotides ........263 17.4. Catabolism of purine and pyrimidine nucleotides. Gout ......265 Part 4.FUNDAMENTALS OF MOLECULAR BIOLOGY AND GENETICS Chapter 18. GENE, GENOME. DNA REPLICATION ......270 18.1. Gene, genome. DNA, RNA: structure, properties...... .270 18.2. Telomeres. Telomerase ............ 281 18.3. DNA technologies............. 284 Chapter 19. mRNA TRANSCRIPTION. RIBOSOMAL TRANSLATION.....288 19.1. mRNA. Transcription: enzymes, mechanisms ......288 19.2. Genetic code. Translation in ribosomes........ 291 19.3. Ribosomal molecular machinery ..........293 Part 5. METABOLIC CONTROL. HORMONES AND VITAMINS Chapter 20. HORMONES-1. BIOCHEMICAL AND CELLULAR MECHANISMS OF HORMONAL REGULATION .......... 301 20.1. Hormones: general definitions......... 301 20.2. Basic principles of hormone effects ..........303 Chapter 21. HORMONES-2. HORMONES OF PEPTIDE AND PROTEIN NATURE... 308 21.1. Peptide and protein hormones of hypothalamus and hypophysis. ....308 21.2. Protein hormones of pancreatic gland......... 321 Chapter 22. HORMONES-3. AMINO ACID DERIVED HORMONES: CATECHOLAMINES, THYREOIDS. LIPOPHILIC HORMONES .... 327 22.1. Catecholamines and other biogenic amines ....... 327 22.2. Thyroid hormones: representatives, pathology ....... 331 22.3. Steroid hormones: representatives, effects, pathology .... 335 22.4. Hormonal regulation of calcium homeostasis. . ..... 342 22.5. Eicosanoids. Biomedical and pharmacological aspects ....346 Chapter 23. BIOCHEMISTRY OF NUTRITION-1. VITAMINS AS ESSENTIAL COMPONENTS OF HUMAN DIET. WATER-SOLUBLE VITAMINS. ... .350 23.1. Biochemistry of nutrition. Components of human diet ....350 23.2. Vitamins: basic definitions, classes of vitamins ....... 352 23.3. Water-soluble vitamins. Vitamins as coenzymes: structure, biochemical properties............ 353 Chapter 24. BIOCHEMISTRY OF NUTRITION-2. VITAMIN C. LIPID-SOLUBLE VITAMINS AS BIOREGULATORS AND ANTIOXYDANTS .... 367 24.1. Vitamin C (ascorbic acid).......... 367 24.2. Vitamin A (retinol): structure, biochemical functions......370 24.3. Vitamin D (calciferol) as calcium and phosphorous homeostasis regulator... 373 24.4. Vitamin E (tocopherol) as principal antioxidant in human body... 375 24.5. Vitamin K: structure of vitamers. Role in blood clotting.... 377 Part 6. BIOCHEMISTRY OF SPECIALIZED TISSUES AND PHYSIOLOGICAL FUNCTIONS Chapter 25. BIOCHEMISTRY OF BLOOD. HEMOSTASIS. COAGULATION CASCADE SYSTEM ............ .380 25.1. Blood: composition, biochemical functions........380 25.2. Hemoglobin: transport of oxygen. Hemoglobinopathies ......382 25.3. Hemostasis: blood clotting, fibrinolysis. ......... .389 Chapter 26. BIOCHEMISTRY OF SPECIALIZED CELLS AND PHYSIOLOGICAL FUNCTIONS. BIOCHEMISTRY OF LIVER. METABOLISM OF XENOBIOTICS. . . . .398 26.1. Liver: survey of major biochemical functions ......398 26.2. Liver: metabolism of heme and bile pigments. Bilirubin transformation. Icterus......... .403 26.3. Liver detoxification function. Biotransformation of xenobiotics and endogenous waste products .........408 Chapter 27. BIOCHEMISTRY OF TOOTH AND SALIVA ..... .415 27.1. Anatomy and physiology of human teeth ......... 415 27.2. Biochemical composition and molecular organization of dental tissues... 417 27.3. Tooth enamel: properties, biochemical composition ...... 417 27.4. Dentin: structure, biochemistry. Periodontum. Cementum ....420 27.5. Tooth pulp: physiology, metabolism ..........426 27.6. Tooth pathology. Caries: biochemical aspects ........ 427 27.7. Biochemical components and functions of saliva......428 Chapter 28. BIOCHEMISTRY OF MUSCLES. MOLECULAR PHYSIOLOGY OF MUSCLE CONTRACTION. .......... .430 28.1. Muscle tissue: general characteristics of functions, structure and biochemistry .............430 28.2. Sliding filament model of muscle contraction. Role of calcium in muscle contraction control .........440 28.3. Regulation of muscle contraction. Role of calcium in muscle contraction control............444 Chapter 29. BIOCHEMISTRY AND MOLECULAR PATHOLOGY OF CONNECTIVE TISSUE ...........446 29.1. Connective tissue: cells and biomolecules ........446 29.2. Structural and adhesive proteins of connective tissue. Structural proteins of extracellular matrix ........450 29.3. Biochemistry of extracellular matrix. Glycosaminoglycans and proteoglycans of connective tissue ....... 457 29.4. Molecular pathology of connective tissue ........462 Chapter 30. BIOCHEMISTRY OF SPECIALIZED CELLS AND PHYSIOLOGICAL FUNCTIONS. BIOCHEMISTRY OF NERVE TISSUE AND NEUROTRANSMITTERS... 466 30.1. Nerve tissue: general characteristics of structure and functions ..466 30.2. Peculiarities of brain biochemical composition and metabolism...469 30.3. Neurotransmitters: classification, receptors, representatives ....470 30.4. Drugs, neurotransmitters and synapses.......483 LIST OF REFERENCES ...........487
Дод.точки доступу:
Губський, Юрій Іванович

Примірників всього: 188
ЧЗ (1), Наук.Аб. (3), Уч.Аб. (184)
Вільні: ЧЗ (1), Наук.Аб. (3), Уч.Аб. (184)

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