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   577.1
   С 40

    Syrovaya, A. O.
    Fundamentals of Bioorganic Chemistry : manual / A. O. Syrovaya, E. R. Grabovetskaya, V. N. Petiunina ; Kharkiv National Medical University, Department of medical and bioorganic chemistry. - Kharkiv : Полосатая типография, 2016. - 188 p. - На англ. мові. - 040.00 р.
Переклад назви: Основи біоорганічної хімії: посібник / В. Сирова та ін.

УДК

577.1(075.8)

Рубрики: БІОХІМІЯ(АНГЛ)--Навчальний посібник

Кл.слова (ненормовані):
навчальні посібники англійською
Анотація: CONTENTS Classification, nomenclature, structure, and reactivity of organic compounds……… Properties of main classes of organic compounds…………………… Acid-base properties of organic compounds……………………………………. Structure, properties and biological importance of carboxylic acids derivatives (Hydroxy acids, Oxoacids, and Phenolic acids)……………………………… Carbohydrates……………………………………………………………………. Higher fatty acids. Lipids. Phospholipids……………………………… Amino acids, peptides, proteins: structure, properties, biological functions………………………………………………………………. Heterocyclic compounds. Structure, properties, and biological functions of nucleic acids………………………………………………………. Biologically important heterofunctional compounds ………………………………
Перейти к внешнему ресурсу https://repo.knmu.edu.ua/bitstream/123456789/19105/1/%D0%A3%D1%87%D0%B5%D0%B1%D0%BD%D0%BE%D0%B5%20%D0%BF%D0%BE%D1%81%D0%BE%D0%B1%D0%B8%D0%B5%20%D0%B0%D0%BD%D0%B3%D0%BB%D0%B8%D0%B9%D1%81%D0%BA%D0%BE%D0%B5%20%D0%BE%D1%80%D0%B3%D0%B0%D0%BD%D0%B8%D0%BA%D0%B0%202016%20%D0%BD%D0%BE%D0%B2%D0%BE%D0%B5.pdf

Дод.точки доступу:
Grabovetskaya, E. R.
Грабовецька Євгенія Романівна
Petiunina , Valentina Nikolaevna
Сирова Ганна Олегівна
Kharkiv National Medical University. Department of medical and bioorganic chemistry

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   577.1
   О-63

    Oraby, Said (Prof.).
    Oraby's Illustrated Review of Biochemistry : For Medical Students and Postgraduates. Part III / by S. Oraby. - 12th ed. - Kalyoub, Egypt : Commercial Press, 2005. - 3, 265 p. : diagram. ; 28 cm. - Загл. обл. : Oraby's Illustrated Reviews of Biochemistry. - На англ. мові. - ISBN 977-224-368-7 : 040.00 р.
Переклад назви: Ілюстрований огляд біохімії Орабі: для студентів-медиків і аспірантів. Ч. III / С. Орабі

УДК

577.1(075.8)

Рубрики: БІОХІМІЯ(АНГЛ)

Кл.слова (ненормовані):
навчальна література англійською
Анотація: Contents Chapter 1: Protein Metabolism. • Protein digestion • Amino acid absorption • Amino acid pool • General catabolic pathways of amino acids: * Transamination * Dcamination * Transdeamination * Decarboxylation • Ammonia • Urea • Catabolism of carbon skeleton of amino acids • Biosynthesis of non-essential amino acids • Conversion of amino acids into specialized products • Protein turnover and nitrogen balance • Nitrogen balance and miscellaneous • Diseases related to protein metabolism • Neurotransmitters Chapter 2: Porphyrins, Heme And Hemoglobin Metabolism • Heme synthesis • Hemoglobin metabolism • Hemoglobin catabolism, bilirubin formation and jaundice Chapter 3: Body fluids. • Blood • Urine • Milk • Semen, CSF and other body fluids Chapter 4: lmmunocltemi.vtry • Antigens Chapter 5: Minerals And Water Metabolism • Macrominerals • Microminerals (iron and other trace elements) • Water metabolism Chapter 6: Acid Base regulation Chapter 7: Nucleotide Metabolism • Bases • Purine metabolism • Pyrimidine metabolism Chapter 8: Molecular Biology (N11cleic Acid Metabolism) . • Nucleic acids (structure and functions) • DNA synthesis (replication) and DNA repair • RNA synthesis (transcription) • Protein synthesis (translation) • Regulation of gene expression • Molecular biology techniques and recombinant DNA technology • Human genome project This book "Oraby's Biochemistry " by SAID ORABY is made in it's four parts (I, II, III and IV) to provide necessary knowledge and recent information about biochemistry for medical students and allied sciences. • All efforts have been made to simplify most of the subjects. • Latest advances in biochemistry important to medicine. • Many illustrations are added to bring biochemistry alive. • Part IV (questions and answers): is a new part (2 volumes) to practice your studying and is the key to success. • Postgraduates and students who are preparing for standard courses or examinations (fellowships, ECFMG. etc) will find this book of benefit for them. • Finally, I hope this work is appreciated and accepted by students and colleagues.
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   577.1
   Ш 19

    Champe, Pamela C..
    Lippincott's Illustrated Reviews: Biochemistry / P. C. Champe, R. A. Harvey ; techn. consult. F. Vella ; comput. graphics M. Cooper. - 2nd ed. - Philadelphia : Lippincott Company, 1994. - xvi, 457 p. : il. ; 28 cm. - (Lippincott's Illustrated Reviews). - На англ. мові. - 100.00 грн.
Переклад назви: Ілюстровані огляди Ліппінкотта: Біохімія / П. Шамп, Р. Харві

УДК

577.1(075.8)

Рубрики: БІОХІМІЯ (АНГЛ)--Навчальний посібник

Кл.слова (ненормовані):
навчальні посібники(англ)
Анотація: This popular study guide and review provide a quick survey of the field of biochemistry, covering the essentials that students need to know. Includes board-type questions to give students experience for what they will encounter in actual examinations. Now thoroughly revised and updated throughout, with much new material on cholesterol and steroid metabolism, nutrition and protein synthesis. Plus, the authors have included a unique cross-referencing system to the book's companion volume, Harvey and Champe's Lippincott's Illustrated Review of Pharmacology. Summarizes and integrates essentials of medical biochemistry. 33 chapters in 7 units: Protein structure and function; Intermediary metabolism; Carbohydrate metabolism; Lipid metabolism; Nitrogen metabolism; Integration of metabolism; Storage and expression of genetic information. Includes study questions for each chapter Brief Contents UNIT I: Protein Structure and Function Chapter 1: Amino Acids 1 Chapter 2: Structure of Proteins 13 Chapter 3: Globular and Fibrous Proteins 25 Chapter 4: Enzymes 47 UNIT II. Intermediary Metabolism Chapter 5: Bioenergetics and Oxidative Phosphorylation 61 Chapter 6: Basic Concepts of Metabolism 75 Chapter 7: Glycolysis 87 Chapter 8: Gluconeogenesis 99 Chapter 9: Citric Acid Cycle 105 Chapter 10: Hexose Monophosphate Pathway 111 UNIT III: Carbohydrate Metabolism Chapter 11: Structure of Carbohydrates 119 Chapter 12: Metabolism of Monosaccharides and Disaccharides 127 Chapter 13: Glycogen Metabolism 135 Chapter 14: Glycosaminoglycans 147 Chapter 15: Glycoproteins 157 UNIT IV: Lipid Metabolism Chapter 16: Metabolism of Dietary Lipids 163 Chapter 17: Fatty Acid and Triacylglycerol Metabolism 171 Chapter 18: Phospholipid Metabolism 191 Chapter 19: Glycolipid Metabolism 199 Chapter 20: Cholesterol and Steroid Metabolism 205 UNIT V: Nitrogen Metabolism Chapter 21: Amino Acids: Disposal of Nitrogen 229 Chapter 22: Amino Acids: Metabolism of Carbon Skeletons 243 Chapter 23: Conversion of Amino Acids to Specialized Products 257 UNIT VI: Integration of Metabolism Chapter 24: Metabolic Effects of Insulin and Glucagon 269 Chapter 25: Metabolism in the Well-Fed State 281 Chapter 26: Metabolism in Starvation, Diabetes Mellitus, and Injury 291 Chapter 27: Nutrition 303 Chapter 28: Vitamins 319 UNIT VII: Storage and Expression of Genetic Information Chapter 29: Nucleotide Metabolism 343 Chapter 30: DNA Structure and Replication 357 -Chapter 31: RNA Structure and Synthesis 377 Chapter 32: Protein Synthesis 389 Chapter 33: Molecular Basis of Inherited Disease 401 Index 421
Дод.точки доступу:
Harvey, Richard A.
Vella, F. \techn. consult.\
Cooper, Michael \comput. graphics.\

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   577.1
   Б 63


    Biological and Bioorganic Chemistry. In 2 books : national textbook. Book 1. Bioorganic Chemistry / B. S. Zimenkovsky, V. A. Muzychenko, I. V. Nizhenkovska, Q. O. Syrova ; ed. B. S. Zimenkovsky, I. V. Nizhenkovska. - 3rd ed. - K. : Medicine Publishing, 2020. - 287 p. - На англ. мові. - Бібліогр.: с. 272. - Index: с. 273-287. - ISBN 978-617-505-791-9 : 260.00 грн.
Переклад назви: Біологічна і біоорганічна хімія. В 2-х кн. Кн. 1: Біоорганічна хімія: підручник / Б. С. Зіменковський, В. А. Музиченко, І. В. Ніженковська, Г. О. Сирова

УДК

577.1(075.8)

Рубрики: БІОХІМІЯ(англ)--Підручник

Кл.слова (ненормовані):
підручники(англ) -- національні підручники -- national textbook
Анотація: The textbook contains the information about the structure, chemical properties and biological role of organic compounds which take part in human metabolic processes: low-molecular bioregulators (vitamins, hormones, other natural and synthetic biologically active compounds, including certain medications and toxic compounds) and biopolymers (carbohydrates, proteins and nucleic acids). This textbook is recommended for students and teachers of higher medical education establishments. PART І. THEORETICAL BASIS OF ORGANIC AND BIOORGANIC CHEMISTRY. THE STRUCTURE OF ORGANIC AND BIOORGANIC COMPOUNDS Сhapter 1. Classification and Nomenclature of Organic Compounds 1.1. Classification of Organic Compounds 1.1.1. Classification Based on the Carbon Chain Structure 1.1.2. Classification Based on the Nature of the Functional Group 1.2. Nomenclature of Organic Compounds Сhapter 2. The Structure of Organic Compounds 2.1. Representation of the Structure of Organic Compounds 2.2. Isomerism of Organic Compounds 2.2.1. Structural Isomerism 2.2.2. Stereoisomerism Сhapter 3. Electronic Conceptions in Organic Chemistry 3.1. Chemical Bonds in Bioorganic Molecules 3.1.1. The Structure of Covalent Bonds 3.1.2. Сharacteristics of Covalent Bonds 3.2. Electronic Effects, the Mutual Effect of Atoms in Molecules 3.2.1. The Inductive Effect 3.2.2. The Mesomeric Effect 3.3. Classification of Chemical Reactions and Reagents. the Mechanism of Chemical Reactions 3.3.1. Classification of Chemical Reactions Based on Their Mechanisms 3.3.2. Classification of Chemical Reactions Based on the Bond Cleavage 3.3.3. The Mechanisms of Chemical Reactions 3.4. The Acid and Base Properties of Organic Compounds 3.4.1. The Theory of Bronsted 3.4.2. The Theory of Lewis PART ІI. HYDROCARBONS AND THEIR DERIVATIVES Сhapter 4. Acyclic Hydrocarbons 4.1. Alkanes 4.1.1. The Structure, Homology, Nomenclature, and Isomerism 4.1.2. Chemical Properties 4.1.3. Industrial and Biomedical Significance 4.2. Alkenes 4.2.1. The Structure, Nomenclature and Isomerism 4.2.2. Chemical Properties 4.3. Alkynes 4.4. Alkadienes Сhapter 5. Carbocyclic Hydrocarbons 5.1. Alicyclic Hydrocarbons 5.1.1. Classification and Nomenclature 5.1.2. Chemical Properties 5.1.3. Biomedical Significance 5.2. Arenes 5.2.1. Classification, Aromaticity 5.2.2. Nomenclature and Isomerism of Mononuclear Arenes 5.2.3. Chemical Properties of Mononuclear Arenes 5.2.4. Polynuclear Arenes Сhapter 6. Halogen Derivatives of Hydrocarbons 6.1. Chemical Properties 6.1.1. Reactions of Nucleophilic Substitution 6.1.2. Reactions of Elimination 6.2. Biomedical Significance Сhapter 7. Hydroxyl Derivatives of Nydrocarbons. Thiols 7.1. Monoatomic Alcohols 7.1.1. Structure, Nomenclature and Isomerism 7.1.2. Chemical Properties 7.1.3. Individual Representatives 7.2. DI- and Polyatomic Alcohols 7.2.1. Structure, Nomenclature and Isomerism 7.2.2. Chemical Properties 7.2.3. Individual Representatives 7.3. Thiols and Thio Ethers 7.3.1. Structure and Nomenclature 7.3.2. Chemical Properties 7.4. Phenols 7.4.1. Structure, Classification and Nomenclature 7.4.2. Chemical Properties 7.4.3. Medical Application Сhapter 8. Amines 8.1. Classification and Nomenclature 8.2. Chemical Properties 8.3. Biological Activity and Toxicity Сhapter 9. Biologically Important Carbonyl Compounds 9.1. Structure and Nomenclature 9.2. Chemical Properties 9.2.1. Oxidation and Reduction Reactions 9.2.2. Reactions of Nucleophilic Addition 9.2.3. Reactions of the Addition-Elimination 9.2.4. Condensation Reactions 9.2.5. α-Carbon Atom Reactions 9.2.6. Polymerization Reactions 9.3. Biomedical Significance Сhapter 10. Carboxylic Acids and Their Functional Derivatives 10.1. Aliphatic and Aromatic Monocarboxylic Acids 10.1.1. Nomenclature 10.1.2. Chemical Properties 10.2. Carbonic Acid Derivatives 10.3. Aliphatic and Aromatic Dicarboxylic Acids 10.3.1. Classification and Nomenclature 10.3.2. Chemical Properties Сhapter 11. Biologically Important Heterofunctional Compounds 11.1. Hydroxy Derivatives of Amines 11.1.1. Amino Alcohols 11.1.2. Aminophenols 11.2. Hydroxy Acids 11.2.1. Aliphatic Hydroxy Acids 11.2.2. Aromatic Hydroxy Acids 11.3. Oxoacids 11.3.1. Some Representatives of Oxoacids 11.3.2. Biosynthesis of Higher Fatty Acids 11.4. Amino Acids 11.4.1. Structure of Amino Acids 11.4.2. Nomenclature and Isomerism of Amino Acids 11.4.3. Chemical Properties 11.5. Derivatives of Para-Amino Benzoic and Sulfanilic Acids PART ІII. BIOLOGICALLY ACTIVE HETEROCYCLIC COMPOUNDS Сhapter 12. Three-, Four- and Five-Membered Heterocyclic Compounds 12.1. Three- and Four-Membered Heterocyclic Compounds 12.2. Five-Membered Heterocycles Containing One Heteroatom 12.2.1. Chemical Properties 12.2.2. Some Representatives Having Biomedical Significance 12.3. Five-Membered Heterocycles Containing Two Heteroatoms 12.3.1. Oxazole and Isooxazole 12.3.2. Thiazole 12.3.3. Pyrazole 12.3.4. The Most Important Derivatives of Pyrazole 12.3.5. Imidazole 12.3.6. The Most Important Derivatives of Imidazole Сhapter 13. Six- and Seven-Membered Heterocyclic Compounds 13.1. Six-Membered Heterocycles Containing One Heteroatom 13.1.1. Six-Membered Heterocycles With Nitrogen Heteroatom 13.1.2. Six-Membered Heterocycles With Oxygen Heteroatom 13.2. Six-Membered Heterocycles Containing Two Heteroatoms 13.2.1. Six-Membered Heterocycles With Two Nitrogen Heteroatoms 13.2.2. Six-Membered Heterocycles With Nitrogen and Sulfur Heteroatoms 13.3. Seven-Membered Heterocycles Сhapter 14. Biologically Important Condensed Heterocyclic Systems, Alkaloids 14.1. Purine Derivatives 14.1.1. Hydroxy Derivatives of Purine 14.1.2. Amino Derivatives of Purine 14.2. Pteridine Derivatives 14.3. Alkaloids 14.3.3. Pyridine and Piperidine Alkaloids 14.3.2. Quinoline Alkaloids 14.3.3. Isoquinoline and Phenanthrene Isoquinoline Alkaloids 14.3.4. Tropane Alkaloids PART ІV. BIOPOLYMERS AND BIOREGULATORS Сhapter 15. Carbohydrates or Saccharides (Sugars) 15.1. Monosaccharides (Monoses) 15.1.1. Isomerism 15.1.2. Tautomerism 15.1.3. Chemical Properties 15.1.4. Individual Representatives 15.1.5. Derivatives of Monosaccharides 15.2. Disaccharides 15.2.1. Reducing Disaccharides 15.2.2. Non-Rreducing Disaccharides 15.3. Higher Polysaccharides 15.3.1. Homopolysaccharides 15.3.2. Heteropolysaccharides Сhapter 16. Proteinogenic Amino Acids, Peptides and Proteins 16.1. Proteinogenic Amino Acids and Their Properties 16.1.1. Isomerism and Structure 16.1.2. Chemical Properties 16.2. Peptides and Proteins 16.2.1. Amino Acid Composition and Amino Acid Sequence 16.2.2. Structural Organization of Proteins 16.2.3. Electrophoresis of Amino Acids and Proteins 16.2.4. Classification of Proteins 16.2.5. Qualitative Reactions on Proteins Сhapter 17. Nucleic Acids. Coenzymes 17.1. Nucleosides 17.2. Nucleotides 17.3. The Structure of Nucleic Acids 17.3.1. The Primary Structure 17.3.2. The Secondary Structure of DNA 17.3.3. The Structure and Functions of RNA 17.4. Nucleotide Coenzymes Сhapter 18. Lipids 18.1. Saponifiable Lipids 18.1.1. Simple Saponifiable Lipids 18.1.2. Complex Saponifiable Lipids 18.2. Nonsaponifiable Lipids 18.2.1. Terpenes 18.2.2. Carotenoids 18.2.3. Steroids 18.2.4. Prostaglandins Answer on the Test for Self Control Recommended Literature List Index
Дод.точки доступу:
Zimenkovsky, Boris Semenovich
Зіменковський Борис Семенович
Muzychenko, Volodymyr Afanasiiovych
Музиченко Володимир Опанасович
Nizhenkovska, Iryna Volodymyrivna
Ніженковська Ірина Володимирівна
Syrova, Ganna Olegivna
Сирова Ганна Олегівна
Zimenkovsky, Boris Semenovich \ред.\
Nizhenkovska, Iryna Volodymyrivna \ред.\

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Вільні: Наук.Аб. (3), Уч.Аб. (5), ННА (6)

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   577.1
   Б 63


    Biological and bioorganic chemistry. In 2 books : [textbook for students of higher medical educational establishments]. Book 2. Biological chemistry / ed. Yu. I. Gubsky, I. V. Nizhenkovska ; Yu. I. Gubsky, I. V. Nizhenkovska, M. M. Korda et al. - 2nd ed. - K. : Medicine Publishing, 2021. - 542 p. : il. - На англ. мові. - Index: p. 535-541. - References: p. 542. - ISBN 978-617-505-886-2 : 360.00 грн.
Переклад назви: Біологічна та біоорганічна хімія. В 2-х кн. Кн. 2. Біологічна хімія: підручник / за ред. Ю. Губського, І. Ніженковської

УДК

577.1(075.8)

Рубрики: БІОХІМІЯ(АНГЛ)--Підручник

Кл.слова (ненормовані):
national textbook -- підручники англійською
Анотація: This textbook contains a systematic presentation of the course of biological chemistry according to the educational program for students of higher medical (pharmaceutical) educational establishments. The core text of this book examines the structure of an enzyme, and the metabolic pathways of the major classes of biomolecules (proteins, amino acids, carbohydrates, lipids, nucleotides, porphyrins); structural features and properties of nucleic acids, DNA and RNA; molecular biology and genetics, biochemical foundations of the physiological functions of the human body and their neurohumoral regulation are highlighted. Considerable attention is paid to the molecular mechanisms underlying the functions of blood cells, liver, kidneys, muscles, connective tissue, immune and nervous systems. The biochemical basis of the pathogenesis of atherosclerosis, diabetes mellitus, obesity, diseases of the endocrine, immune, nervous systems and connective tissue are considered. In addition to informational material, each chapter of the textbook contains tests and tasks for self-control. Introduction. History of development of biochemistry PART I. GENERAL PRINCIPLES OF REGULATION OF METABOLISM Chapter 1. Biomolecules and cellular structures 1.1. Chemical composition of living organism 1.2. Biomolecules and their functions 1.3. Scheme of structure of prokaryotic and eukaryotic cells 1.4. Biological membranes Chapter 2. Enzymes 2.1. Enzymes: structure, properties and classification 2.2. Mechanism of the enzyme action 2.3. Kinetics of enzymatic reactions. The units of enzymatic activity 2.4. Regulation of enzymatic processes 2.5. Medical enzymology 2.6. Cofactors and coenzymes: chemical structure and functions Chapter 3. Fundamental regularities of metabolism. Tricarboxylic acid cycle 3.1. Common pathways of protein, lipid, and carbohydrate metabolism 3.2. Oxidative decarboxylation of pyruvic acid 3.3. Tricarboxylic acid cycle or Krebs cycle Chapter 4. Molecular foundations of bioenergetics 4.1. Pathways of the oxygen consumption in the reactions of biological oxidation 4.2. Tissue respiration 4.3. Chemiosmotic mechanism of ATP synthesis in mitochondria 4.4. Non-phosphorylative oxidation in electron trasport chain as the mechanism of heat production in the mitochondria 4.5. Inhibitors and uncouplers of oxidative phosphorylation Chapter 5. Hormonal regulation of metabolism 5.1. General characteristics of hormones 5.2. Classification of hormones 5.3. Mechanism of action of hydrophilic hormones 5.4. Mechanism of action of hormones that interact with the intracellular receptors 5.5. Regulation of secretion of hormones PART II. CARBOHYDRATE, LIPID AND AMINO ACID METABOLISM. REGULATION OF CARBOHYDRATE, LIPID AND AMINO ACID METABOLISM Chapter 6. Carbohydrate metabolism. Regulation of carbohydrate metabolism 6.1. Glycolysis 6.2. Alcohol fermentation 6.3. Pentose phosphate pathway of glucose metabolism 6.4. Metabolism of fructose 6.5. Metabolism of sorbitol 6.6. Metabolism of galactose 6.7. Gluconeogenesis 6.8. Metabolism of glycogen 6.9. Regulation of glycogenolysis and glycogenesis Chapter 7. Lipid metabolism. Regulation of lipid metabolism 7.1. Metabolism of triacylglycerols 7.2. Metabolism of fatty acids 7.3. Metabolism of glycerol 7.4. Ketone body formation and utilization in normal and pathological conditions 7.5. Metabolism of phospholipids 7.6. Metabolism of cholesterol 7.7. Disorders of lipid metabolism Chapter 8. Amino acid metabolism. Enzymopathies of amino acid metabolism 8.1. General pathways of amino acids transformation 8.2. Formation and detoxification of ammonia. Urea cycle 8.3. Specialized pathways of acyclic and cyclic amino acids 8.4. Biosynthesis of porphyrins 8.5. Hereditary disorder of porphyrin metabolism PART III. MOLECULAR BIOLOGY. BIOCHEMISTRY OF INTERCELLULAR COMMUNICATIONS Chapter 9. Metabolism of nucleotides 9.1. Biosynthesis and catabolism of purine and pyrimidine nucleotides 9.2. Disorders of purine and pyrimidine metabolism Chapter 10. Fundamentals of molecular biology 10.1. Structure of deoxyribonucleic acid 10.2. Biosynthesis of deoxyribonucleic acid 10.3. Biosynthesis of ribonucleic acid (RNA) 10.4. Ribosomal protein syntesis (translation) 10.5. Antibiotics are inhibitors of template synthesis 10.6. Viruses and toxins are inhibitors of template synthesis in eukaryotic cells 10.7. Biochemical mechanism of antiviral effect of interferons Chapter 11. Fundamentals of molecular genetics 11.1. Phases of eukaryotic cell cycle. Biochemical mechanism of control of cell entry into mitosis 11.2. Molecular mechanism of mutations 11.3. Genetic recombinations 11.4. Amplification of genes (genes of metallothionein, dihydrofolate reductase) 11.5. Genetic engineering: some basic concepts, biomedical significance Chapter 12. Biochemistry of hormonal regulation 12.1. Hormones of hypotalamic-pituitary system 12.2. Pancreatic hormones 12.3. Hormones of digestive system 12.4. Hormones of thyroid gland 12.5. Hormonal regulation of calcium homeostasis 12.6. Steroid hormones of adrenal glands and gonads 12.7. Biological active eicosanoids 12.8. Eicosanoids in the inflammation Part IV. FUNCTIONAL BIOCHEMISTRY Chapter 13. Biochemystry of human nutrition 13.1. Macronutrients 13.2. Biochemical role of microelements 13.3. Digestion of nutrients in the digestive tract 13.4. Violations of digestion in alimentary canal 13.5. Vitamins Chapter 14. Biochemistry of blood 14.1. Respiratory function of red blood cells 14.2. Normal and pathological forms of hemoglobin 14.3. Acid-base balance and buffer systems of blood 14.4. Non-protein components of plasma 14.5. Blood proteins 14.6. Blood plasma lipoproteins 14.7. Blood coagulation, anticoagulant and fibrinolytic systems Chapter 15. Biochemistry of immune processes 15.1. Immunoglobulins: structure, biological functions 15.2. Mediators and hormones of immune system 15.3. Biochemical components of human complement system 15.4. Biochemical mechanisms of development of immunodeficiency Chapter 16. Biochemical functions of the liver 16.1. Bile formation in liver 16.2. Metabolism of bile pigments in the liver 16.3. Pathobiochemistry ofjaundice 16.4. Biochemical disturbances in certain liver diseases 16.5. Biotransformation of xenobiotics and endogenous toxins Chapter 17. Biochemical functions of the kidneys 17.1. Steps of urine formation 17.2. Physical characteristics of urine 17.3. Chemical composition of urine 17.4. Role of the kidneys in acid-base balance 17.5. Features of kidney metabolism 17.6. Biochemical tests of kidney function Chapter 18. Biochemistry of muscles 18.1. Structure of myofibrils 18.2. Chemical composition of muscle tissue 18.3. Biochemical features of cardiac and smooth muscles 18.4. Biochemical mechanisms of contraction and relaxation of muscles 18.5. Sources of energy for muscle constractions 18.6. Biochemical changes in muscle pathology Chapter 19. Biochemistry of connective tissue 19.1. Structure and metabolism of collagen 19.2. Elastin structure 19.3. Structure and metabolism of proteoglycans 19.4. Structure of glycoproteins Chapter 20. Biochemistry of nervous system 20.1. Chemical composition of the nervous system 20.2. Nervous tissue metabolism 20.3. Molecular basis of bioelectrical processes on the membrane of neurons 20.4. Neurotransmitters 20.5. Metabolism of neurotransmitters and neuromodulators in mental disorders 20.6. Neurochemical mechanisms of psychotropic drugs Answers for tests for self-control Index References
Дод.точки доступу:
Gubsky, Yuriy I.
Губський Юрій Іванович
Nizhenkovska, Iryna Volodymyrivna
Ніженковська Ірина Володимирівна
Korda, Mykhaylo Mykhaylovych
Корда Михайло Михайлович
Borzenko, B. G.
Brazaluk, O. Z.
Ersteniuk, G. M.
Efetov, K. O.
Zhukov, V. I.
Zaichko, N. V.
Komarevtseva, I. O.
Lutsyuk, M. B.
Neporada, K. S.
Непорада Каріне Степанівна
Tarasenko, L. M.
Тарасенко Лідія Максимівна et al.
Gubsky, Yuriy I. \ed.\
Nizhenkovska, Iryna Volodymyrivna \ed.\

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   577.1
   Б 63


    Biological and bioorganical chemistry : teaching textbook / A. A. Mardashko, L. M. Mironovych, G. F. Stepanov, O. V. Storchilo. - K. : Caravela, 2020. - 240 p. : scheme. - На англ. мові. - References: p. 240. - ISBN 978-966-2229-05-9 : 050.00 грн.
Переклад назви: Біологічна та біоорганічна хімія: навчальний посібник / О. О. Мардашко та ін.

УДК

577.1(075.8)

Рубрики: БІОХІМІЯ(АНГЛ)--Навчальний посібник

Кл.слова (ненормовані):
навчальні посібники(англ)
Анотація: CONTENTS Section I. Biologically important classes of bioorganic compounds. Biopolymers and their structural components....7 Chapter 1. Theoretical basis of the structure and reactivity of bioorganic compounds..............7 1.1. Classification, nomenclature and isomerism of bioorganic compounds. The nature of chemical bonds...........7 1.2. Classification of chemical reactions. Reactivity of alkanes, alkenes, arenes. alcohols, phenols, amines.......... 14 1.3. Structure and properties of aldehydes and ketones....... 19 1.4. Oxidation of aldehydes and ketones ...........22 1.4. Structure, properties and biological significance of carboxylic acids........................ 24 Chapter 2. Higher fatty acids. Lipids. Phospholipids. a-amino acids, peptides, proteins.................27 2.1. Higher fatty acids. Lipids. Phospholipids.........27 2.2. Amino acid composition of proteins and peptides........ 31 2.3. Structural organization of proteins. Physico-chemical properties of proteins. Reactions deposition of proteins. Denaturation Levels of the structure of protein molecules.............40 Chapter 3. Carbohydrates. Monosaccharides. Oligo-and polysaccharides ................45 3.1. Carbohydrates. The structure and chemical properties of monosaccharides....................45 Chapter 4. Biologically active heterocyclic compounds. Nucleosides, nucleotides, nucleic acids ............52 4.1. Classification, structure and significance of heterocyclic compounds....................... 52 4.2. Structure and biochemical functions of nucleosides and nucleotides....................... 60 4.3. Structure and biological role of nucleic acids.........61 Section II. The general pattern of metabolism.......... 65 Chapter 5. The biochemical components of cells........65 Chapter 6. Enzymes and coenzymes, coenzyme function of vitamins. Regulation of metabolism............68 6.1. Enzymes. Structure, physico-chemical properties of proteins. enzymes, classified by type of reaction ............68 6.2. Mechanism of action and determination of enzyme activity.... 70 6.3. Kinetics of enzymatic catalysis. Enzyme inhibitors..... 70 6.4. Cofactors and coenzymes. Coenzyme functions of vitamins ...72 Chapter 7. Basic laws of metabolism Citric acid cycle...... 74 7.1. Metabolism. Catabolism, anabolism. The general path of reform of proteins, carbohydrates, lipids.............74 7.2. Citric acid cycle .....................75 Chapter 8. Molecular Basis ofbioenergetics......... 77 8.1. Bioenergetics processes: biological oxidation, oxidative phosphorylation, ATP synthesis............... 77 8.2. Chemiosmotic theory of oxidative phosphorylation. Inhibitors and uncouplers of oxidative phosphorylation.... 80 8.3. Shuttle transport mechanisms across the membrane of mitochondria................... 86 8.4. The formation of free radicals, peroxides and antioxidants... 90 Section III. Metabolism of carbohydrates, lipids, aniino acids and its regulation.................93 Chapter 9. Carbohydrate metabolism and its regulation...... 93 9.1. Metabolism of carbohydrates. Anaerobic oxidation of glucose -glycolysis and glycogen - glycogenolysis...........93 9.2. Aerobic oxidation of glucose. Alternative ways of sharing monosaccharides. The metabolism of fructose and galactose. Pentose phosphate pathway...............97 9.3. Biosynthesis of glucose - gluconeogenesis and glycogen biosynthesis. Genetic metabolic glycogen......... 103 Chapter 10. Lipid metabolism and its regulation....... 10 8 10.1. Lipid Metabolism: catabolism of triacyl glycerols, the regulation of lipolysis. Metabolism of ketone bodies..................... 108 10.2. The biosynthesis of the active form of higher fatty acids.. 114 10 3 Biosynthesis and biotransformation of cholesterol, bile acids. Pathology of lipid metabolism: steatorreya, obesity, atherosclerosis................. . 119 Chapter 11. Metabolism ofamino acids. Enzymopathology ofamino acid metabolism..... 124 11.1. General ways ofamino acids transformation......... 125 11.2 Detoxication of ammonia, urea biosynthesis....... 129 11.3. Specialized ways of sharing the noncyclic and cyclic amino acids. The biosynthesis of glutathione and creatine. Enzymopathology ofamino acid metabolism........ 132 Section IV. Molecular Biology. Biochemistry of intercellular communication........... 141 Chapter 12. Fundamentals of molecular biology......... 141 12.1. Biochemical functions of nucleotides and nucleic acids ... 141 12.2. Biosynthesis and catabolism of purine and pyrimidine nucleotides. Hereditary metabolic uric acid disturbances.. 141 12.3. Enzymes and molecular mechanisms of DNA replication. Transcription - RNA biosynthesis............. 147 12.4. Protein biosynthesis in ribosomes. Stages and mechanism of translation, regulation of broadcasting. Antibiotics inhibitors of transcription and translation.............. 150 Chapter 13, Basics of molecular genetics............ 153 13.1. Regulation of gene expression in prokaryotes and eukaryotes 153 13.2. Molecular mechanisms of mutations. DNA reparation... 154 Chapter 14. Molecular mechanisms of hormones action on target cells................ 155 14.1. Molecular-cellular mechanisms of the hormonal signal transfer..................... 155 Chapter 15. Biochemistry hormonal regulation........ 159 15.1. Hormonal regulation of metabolism and cellular functions: the hormones of the hypothalamic-pituitary and thyroid gland. Regulation of calcium homeostasis ........... 159 15.2. Hormones of the pancreas. Regulation of carbohydrate metabolism...................... 16615.3. Hormones of adrenal and sex glands. Physiologically active eicosanoids........... 17o Section V. Biochemistry of tissues and physiological functions............ 133 Chapter 16. Biochemistry of human nutrition. Nutrition.... 183 16.1. Mechanisms of digestion of nutrients in the digestive tract. 183 16.2. Vitamins as components of nutrition: exogenous and endogenous hypovitaminosis........... 187 16.3. Lipid-soluble vitamins, antioxidants.......... 196 Chapter 17. Biochemistry andpatobioh emistry of blood...... 201 17.1. Biochemical composition of blood in health and disease: acute phase inflammatory proteins, enzymes of blood plasma............... 201 17.2. Non-proteinaceous nitrogen-containing and nitrogen-free organic components of blood. Plasma lipoproteins.....203 17.3. The respiratory function oferythrocytes. Acid-base status, the buffer system of blood ................205 17.4. Coagulant, anticoagulant and fibrtynolytic system of blood ...209 17.5. Biochemistry of immune processes and biochemical mechanisms of immunodeficiency condition.........216 Chapter 18. Functional and clinical biochemistry of organs and tissues............218 18.1. Biochemical functions of the liver. Porphyrin metabolism: the metabolism of bile pigments, Biochemistry ofjaundice.218 18.2. Biotransformation of xenobiotics and endogenous toxins in the liver: microsomal oxidation, cytochrome P-450...223 18.3. Urine production in kidney. Normal and pathological components of urine............ ...... 224 18.4. Biochemistry of muscle, muscle contraction and connective tissue......... .........229 18.5. Biochemistry of nervous tissue. Pathobiochemistry of mental disorders............ 235 REFERENCES............ -----240
Дод.точки доступу:
Mardashko, A. A.
Мардашко Олексій Олексійович
Mironovych, L. M.
Миронович Людмила Максимівна
Stepanov, G. F.
Степанов Генадій Федорович
Storchilo, O. V.
Сторчило Ольга В'ячеславівна

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   577.1
   Г 93

    Gubsky, Yuriy I..
    Bioorganic Chemistry : textbook for the students of medical universities [of the IVth level of accreditation with English as language of instruction] / Yu. Gubsky = Біоорганічна хімія : підручник для студентів мед. університетів / Ю. І. Губський. - 2nd ed.=2-ге вид. - Vinnytsya=Вінниця : Nova knyha=Нова Книга, 2019. - 223 p. - На англ. мові. - Suggested readigs: с. 218. - Index: с. 218-223. - ISBN 978-966-382-777-3 : 285.00 грн

УДК

577.1(075.8)

Рубрики: БІООРГАНІЧНА ХІМІЯ(АНГЛ)--Підручник

Кл.слова (ненормовані):
підручники
Дод.точки доступу:
Губський, Юрій Іванович

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ЧЗ (1), Наук.Аб. (3), Гурт.4 (1), Уч.Аб. (139), ННА (1)
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   577.1
   Б 63


    Biological and Bioorganic Chemistry. In 2 books : national textbook. Book 1. Bioorganic Chemistry / B. S. Zimenkovsky, V. A. Muzychenko, I. V. Nizhenkovska, Q. O. Syrova ; ed. B. S. Zimenkovsky, I. V. Nizhenkovska. - 2nd ed. - K. : Medicine Publishing, 2019. - 287 p. - На англ. мові. - Бібліогр.: с. 272. - Index: с. 273-287. - ISBN 978-617-505-757-5 : 260.00 грн., 130.00 грн.
Переклад назви: Біологічна і біоорганічна хімія. В 2-х кн. Кн. 1: Біоорганічна хімія: підручник / Б. С. Зіменковський, В. А. Музиченко, І. В. Ніженковська, Г. О. Сирова

УДК

577.1(075.8)

Рубрики: БІОХІМІЯ(англ)--Підручник

Кл.слова (ненормовані):
підручники(англ)
Анотація: The textbook contains the information about the structure, chemical properties and biological role of organic compounds which take part in human metabolic processes: low-molecular bioregulators (vitamins, hormones, other natural and synthetic biologically active compounds, including certain medications and toxic compounds) and biopolymers (carbohydrates, proteins and nucleic acids). This textbook is recommended for students and teachers of higher education establishments — medical universities, institutes and academies Abbreviations.............................. 8 Preface............................... .9 Introduction. The subject, history of bioorganic chemistry development, its Value as a science......................... ...11 PART І. Theoretical Basis of organic and Bioorganic Chemistry. The Structure of Organic and Bioorganic Compounds............12 Chapter 1. Classification and Nomenclature of Organic Compounds.......12 1.1. Classification of Organic Compounds.............. ...12 1.1.1. Classification Based on the Carbon Chain Structure .......... ..12 1.1.2. Classification Based on the Nature of the Functional Group........ 13 1.2. Nomenclature of Organic Compounds................. 14 Chapter 2. The Structure of Organic Compounds............. .18 2.1. Representation of the Structure of Organic Compounds.......... 18 2.2. Isomerism of Organic Compounds............... 18 2.2.1. Structural Isomerism....................... 18 2.2.2. Stereoisomerism........................ 19 Chapter 3. Electronic Conceptions in Organic Chemistry......... 25 3.1. Chemical Bonds in Bioorganic Molecules............. .....25 3.1.1. The Structure of Covalent Bonds................. ...25 3.1.2. Сharacteristics of Covalent Bonds................ ...26 3.2. Electronic Effects, the Mutual Effect of Atoms in Molecules......... 27 3.2.1. The Inductive Effect........................ 27 3.2.2. The Mesomeric Effect........................ 28 3.3. Classification of Chemical Reactions and Reagents. the Mechanism of Chemical Reactions............... .....29 3.3.1. Classification of Chemical Reactions Based on Their Mechanisms....... 29 3.3.2. Classification of Chemical Reactions Based on the Bond Cleavage........ 30 3.3.3. The Mechanisms of Chemical Reactions............... ....30 3.4. The Acid and Base Properties of Organic Compounds.......... 31 3.4.1. The Theory of Bronsted..................... .....31 3.4.2. The Theory of Lewis.......................... 32 PART ІI. HYDROCARBONS AND THEIR DERIVATIVES......... .....34 Chapter 4. Acyclic Hydrocarbons..................... 34 4.1. Alkanes............................. 34 4.1.1. The Structure, Homology, Nomenclature, and Isomerism.......... ..34 4.1.2. Chemical Properties..................... .....35 4.1.3. Industrial and Biomedical Significance................. 36 4.2. Alkenes............................. 37 4.2.1. The Structure, Nomenclature and Isomerism................ 37 4.2.2. Chemical Properties.......................... 38 4.3. Alkynes..............................40 4.4. Alkadienes.............................. 40 Chapter 5. Carbocyclic Hydrocarbons................... 43 5.1. Alicyclic Hydrocarbons......................... 43 5.1.1. Classification and Nomenclature.................. .....43 5.1.2. Chemical Properties..................... ...43 5.1.3. Biomedical Significance......................... 44 5.2. Arenes.......................... .....44 5.2.1. Classification, Aromaticity...................... 44 5.2.2. Nomenclature and Isomerism of Mononuclear Arenes............ 45 5.2.3. Chemical Properties of Mononuclear Arenes............ .....45 5.2.4. Polynuclear Arenes.......................... 48 Chapter 6. Halogen Derivatives of Hydrocarbons............... 53 6.1. Chemical Properties........................ 53 6.1.1. Reactions of Nucleophilic Substitution................... 53 6.1.2. Reactions of Elimination .................... ....54 6.2. Biomedical Significance........................ 54 Chapter 7. Hydroxyl Derivatives of Nydrocarbons. Thiols........... ....56 7.1. Monoatomic Alcohols........................56 7.1.1. Structure, Nomenclature and Isomerism................ ....56 7.1.2. Chemical Properties.......................... 57 7.1.3. Individual Representatives..................... ....59 7.2. DI- and Polyatomic Alcohols ..................... 60 7.2.1. Structure, Nomenclature and Isomerism................. 60 7.2.2. Chemical Properties.......................... 60 7.2.3. Individual Representatives....................... 62 7.3. Thiols and Thio Ethers......................... 62 7.3.1. Structure and Nomenclature.................. .....62 7.3.2. Chemical Properties..................... .....63 7.4. Phenols......................... .......66 7.4.1. Structure, Classification and Nomenclature ................. 66 7.4.2. Chemical Properties..................... .....66 7.4.3. Medical Application......................... 68 Chapter 8. Amines............................ 70 8.1. Classification and Nomenclature................ ....70 8.2. Chemical Properties.................... ......71 8.3. Biological Activity and Toxicity..................... 75 Chapter 9. Biologically Important Carbonyl Compounds............. 77 9.1. Structure and Nomenclature..................... 77 9.2. Chemical Properties.......................... 78 9.2.1. Oxidation and Reduction Reactions..................... 78 9.2.2. Reactions of Nucleophilic Addition.................. ......80 9.2.3. Reactions of the Addition-Elimination................. ......83 9.2.4. Condensation Reactions........................ 85 9.2.5. α-Carbon Atom Reactions..................... ....86 9.2.6. Polymerization Reactions ......................... 87 9.3. Biomedical Significance........................ 87 Chapter 10. Carboxylic Acids and Their Functional Derivatives........ ..89 10.1. Aliphatic and Aromatic Monocarboxylic Acids................ 89 10.1.1. Nomenclature........................... 89 10.1.2. Chemical Properties.......................... 91 10.2. Carbonic Acid Derivatives.................. .....103 10.3. Aliphatic and Aromatic Dicarboxylic Acids........... .......106 10.3.1. Classification and Nomenclature.................. ......106 10.3.2. Chemical Properties..................... ....107 Chapter 11. Biologically Important Heterofunctional Compounds...... ....110 11.1. Hydroxy Derivatives of Amines ............... ......110 11.1.1. Amino Alcohols........................ .......110 11.1.2. Aminophenols........................... 112 11.2. Hydroxy Acids.............................112 11.2.1. Aliphatic Hydroxy Acids.................... .....113 11.2.2. Aromatic Hydroxy Acids .................. ......119 11.3. Oxoacids......................... ......121 11.3.1. Some Representatives of Oxoacids................... 121 11.3.2. Biosynthesis of Higher Fatty Acids..................... 124 11.4. Amino Acids ...................... ......126 11.4.1. Structure of Amino Acids........................ 126 11.4.2. Nomenclature and Isomerism of Amino Acids............. .......126 11.4.3. Chemical Properties .................... .......127 11.5. Derivatives of Para-Amino Benzoic and Sulfanilic Acids ............ 131 PART ІII. BIOLOGICALLY ACTIVE HETEROCYCLIC COMPOUNDS........... 134 Chapter 12. Three-, Four- and five-membered Heterocyclic Compounds...... 134 12.1. Three- and four-membered Heterocyclic Compounds...... ........134 12.2. Five-Membered heterocycles containing one heteroatom ... ........136 12.2.1. Chemical Properties..................... .....136 12.2.2. Some Representatives Having Biomedical Significance......... .....139 12.3. Five-membered heterocycles containing two heteroatoms ......... 142 12.3.1. Oxazole and Isooxazole................... ......143 12.3.2. Thiazole............................... 143 12.3.3. Pyrazole............................... 144 12.3.4. The Most Important Derivatives of Pyrazole............ .......145 12.3.5. Imidazole.............................. 145 12.3.6. The Most Important Derivatives of Imidazole........... .......146 Chapter 13. Six- and seven-membered heterocyclic compounds......... 148 13.1. Six-Membered Heterocycles containing one heteroatom ........... 148 13.1.1. Six-Membered Heterocycles with Nitrogen Heteroatom....... ........148 13.1.2. Six-Membered Heterocycles with Oxygen Heteroatom ............... 155 13.2. Six-Membered Heterocycles containing two heteroatoms ... ........156 13.2.1. Six-Membered Heterocycles with Two Nitrogen Heteroatoms ...... ........156 13.2.2. Six-Membered Heterocycles with Nitrogen and Sulfur Heteroatoms .... ......160 13.3. Seven-Membered Heterocycles............... ........161 Chapter 14. Biologically Important Condensed Heterocyclic Systems, Alkaloids... 164 14.1. purine derivatives ..................... .......164 14.1.1. Hydroxy Derivatives of Purine................. .......165 14.1.2. Amino Derivatives of Purine........................ 167 14.2. pteridine derivatives ........................... 168 14.3. Alkaloids ................................. 169 14.3.3. Pyridine and Piperidine Alkaloids....................... 169 14.3.2. Quinoline Alkaloids...................... .......170 14.3.3. Isoquinoline and Phenanthrene Isoquinoline Alkaloids.............. 170 14.3.4. Tropane Alkaloids..................... .......171 PART ІV. BIOPOLYMERS AND BIOREGULATORS ......... .........174 Chapter 15. Carbohydrates or Saccharides (Sugars)............. .....174 15.1. Monosaccharides (Monoses)........................ 175 15.1.1. Isomerism.......................... .........176 15.1.2. Tautomerism......................... .........177 15.1.3. Chemical Properties ........................... 180 15.1.4. Individual Representatives......................... 189 15.1.5. Derivatives of Monosaccharides...................... 192 15.2. Disaccharides.............................. 194 15.2.1. Reducing Disaccharides..........................195 15.2.2. Non-Rreducing Disaccharides.................. .......201 15.3. Higher Polysaccharides..........................202 15.3.1. Homopolysaccharides .................... ........202 15.3.2. Heteropolysaccharides........................... 207 Chapter 16. Proteinogenic Amino Acids, Peptides and Proteins ........... 212 16.1. Proteinogenic amino acids and their properties ................ 212 16.1.1. Isomerism and Structure.................... ........212 16.1.2. Chemical Properties .............................216 16.2. Peptides and proteins ........................... 224 16.2.1. Amino Acid Composition and Amino Acid Sequence ........ .......224 16.2.2. Structural Organization of Proteins ....................... 228 16.2.3. Electrophoresis of Amino Acids and Proteins ............. ......233 16.2.4. Classification of Proteins ......................... 234 16.2.5. Qualitative Reactions on Proteins ...................... 235 Chapter 17. Nucleic Acids. Coenzymes.................. ......237 17.1. Nucleosides.............................. 239 17.2. Nucleotides............................... 240 17.3. The structure of Nucleic acids ....................... 241 17.3.1. The Primary Structure ................... .......241 17.3.2. The Secondary Structure of DNA............... .........243 17.3.3. The Structure and Functions of RNA...................... 245 17.4. Nucleotide Coenzymes ......................... 246 Chapter 18. Lipids.............................. 251 18.1. Saponifiable Lipids...................... ..........251 18.1.1. Simple Saponifiable Lipids........................... 251 18.1.2. Complex Saponifiable Lipids.......................... 254 18.2. Nonsaponifiable Lipids .................... ..........259 18.2.1. Terpenes................................ 259 18.2.2. Carotenoids........................ .......262 18.2.3. Steroids................................ 263 18.2.4. Prostaglandins ............................. 268 Answer on the Test for Self Control.......................... 271 Recommended Literature List............................ 272 INDEX............................... .......273
Дод.точки доступу:
Zimenkovsky, Boris Semenovich
Зіменковський Борис Семенович
Muzychenko, Volodymyr Afanasiiovych
Музиченко Володимир Опанасович
Nizhenkovska, Iryna Volodymyrivna
Ніженковська Ірина Володимирівна
Syrova, Ganna Olegivna
Сирова Ганна Олегівна
Zimenkovsky, Boris Semenovich \ред.\
Nizhenkovska, Iryna Volodymyrivna \ред.\

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Наук.Аб. (4), Уч.Аб. (1)
Вільні: Наук.Аб. (4), Уч.Аб. (1)

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   577.1
   Б 63


    Biological and Bioorganic Chemistry. In 2 books : national textbook. Book 1. Bioorganic Chemistry / B. S. Zimenkovsky, V. A. Muzychenko, I. V. Nizhenkovska, Q. O. Syrova ; ed. B. S. Zimenkovsky, I. V. Nizhenkovska. - K. : Medicine Publishing, 2018. - 287 p. - На англ. мові. - Бібліогр.: с. 272. - Index: с. 273-287. - ISBN 978-617-505-666-0 : 130.00 грн.
Переклад назви: Біологічна і біоорганічна хімія. В 2-х кн. Кн. 1: Біоорганічна хімія: підручник / Б. С. Зіменковський, В. А. Музиченко, І. В. Ніженковська, Г. О. Сирова

УДК

577.1(075.8)

Рубрики: БІОХІМІЯ(англ)--Підручник

Кл.слова (ненормовані):
підручники(англ)
Анотація: The textbook contains the information about the structure, chemical properties and biological role of organic compounds which take part in human metabolic processes: low-molecular bioregulators (vitamins, hormones, other natural and synthetic biologically active compounds, including certain medications and toxic compounds) and biopolymers (carbohydrates, proteins and nucleic acids). This textbook is recommended for students and teachers of higher education establishments — medical universities, institutes and academies Abbreviations.............................. 8 Preface............................... .9 Introduction. The subject, history of bioorganic chemistry development, its Value as a science......................... ...11 PART І. Theoretical Basis of organic and Bioorganic Chemistry. The Structure of Organic and Bioorganic Compounds............12 Chapter 1. Classification and Nomenclature of Organic Compounds.......12 1.1. Classification of Organic Compounds.............. ...12 1.1.1. Classification Based on the Carbon Chain Structure .......... ..12 1.1.2. Classification Based on the Nature of the Functional Group........ 13 1.2. Nomenclature of Organic Compounds................. 14 Chapter 2. The Structure of Organic Compounds............. .18 2.1. Representation of the Structure of Organic Compounds.......... 18 2.2. Isomerism of Organic Compounds............... 18 2.2.1. Structural Isomerism....................... 18 2.2.2. Stereoisomerism........................ 19 Chapter 3. Electronic Conceptions in Organic Chemistry......... 25 3.1. Chemical Bonds in Bioorganic Molecules............. .....25 3.1.1. The Structure of Covalent Bonds................. ...25 3.1.2. Сharacteristics of Covalent Bonds................ ...26 3.2. Electronic Effects, the Mutual Effect of Atoms in Molecules......... 27 3.2.1. The Inductive Effect........................ 27 3.2.2. The Mesomeric Effect........................ 28 3.3. Classification of Chemical Reactions and Reagents. the Mechanism of Chemical Reactions............... .....29 3.3.1. Classification of Chemical Reactions Based on Their Mechanisms....... 29 3.3.2. Classification of Chemical Reactions Based on the Bond Cleavage........ 30 3.3.3. The Mechanisms of Chemical Reactions............... ....30 3.4. The Acid and Base Properties of Organic Compounds.......... 31 3.4.1. The Theory of Bronsted..................... .....31 3.4.2. The Theory of Lewis.......................... 32 PART ІI. HYDROCARBONS AND THEIR DERIVATIVES......... .....34 Chapter 4. Acyclic Hydrocarbons..................... 34 4.1. Alkanes............................. 34 4.1.1. The Structure, Homology, Nomenclature, and Isomerism.......... ..34 4.1.2. Chemical Properties..................... .....35 4.1.3. Industrial and Biomedical Significance................. 36 4.2. Alkenes............................. 37 4.2.1. The Structure, Nomenclature and Isomerism................ 37 4.2.2. Chemical Properties.......................... 38 4.3. Alkynes..............................40 4.4. Alkadienes.............................. 40 Chapter 5. Carbocyclic Hydrocarbons................... 43 5.1. Alicyclic Hydrocarbons......................... 43 5.1.1. Classification and Nomenclature.................. .....43 5.1.2. Chemical Properties..................... ...43 5.1.3. Biomedical Significance......................... 44 5.2. Arenes.......................... .....44 5.2.1. Classification, Aromaticity...................... 44 5.2.2. Nomenclature and Isomerism of Mononuclear Arenes............ 45 5.2.3. Chemical Properties of Mononuclear Arenes............ .....45 5.2.4. Polynuclear Arenes.......................... 48 Chapter 6. Halogen Derivatives of Hydrocarbons............... 53 6.1. Chemical Properties........................ 53 6.1.1. Reactions of Nucleophilic Substitution................... 53 6.1.2. Reactions of Elimination .................... ....54 6.2. Biomedical Significance........................ 54 Chapter 7. Hydroxyl Derivatives of Nydrocarbons. Thiols........... ....56 7.1. Monoatomic Alcohols........................56 7.1.1. Structure, Nomenclature and Isomerism................ ....56 7.1.2. Chemical Properties.......................... 57 7.1.3. Individual Representatives..................... ....59 7.2. DI- and Polyatomic Alcohols ..................... 60 7.2.1. Structure, Nomenclature and Isomerism................. 60 7.2.2. Chemical Properties.......................... 60 7.2.3. Individual Representatives....................... 62 7.3. Thiols and Thio Ethers......................... 62 7.3.1. Structure and Nomenclature.................. .....62 7.3.2. Chemical Properties..................... .....63 7.4. Phenols......................... .......66 7.4.1. Structure, Classification and Nomenclature ................. 66 7.4.2. Chemical Properties..................... .....66 7.4.3. Medical Application......................... 68 Chapter 8. Amines............................ 70 8.1. Classification and Nomenclature................ ....70 8.2. Chemical Properties.................... ......71 8.3. Biological Activity and Toxicity..................... 75 Chapter 9. Biologically Important Carbonyl Compounds............. 77 9.1. Structure and Nomenclature..................... 77 9.2. Chemical Properties.......................... 78 9.2.1. Oxidation and Reduction Reactions..................... 78 9.2.2. Reactions of Nucleophilic Addition.................. ......80 9.2.3. Reactions of the Addition-Elimination................. ......83 9.2.4. Condensation Reactions........................ 85 9.2.5. α-Carbon Atom Reactions..................... ....86 9.2.6. Polymerization Reactions ......................... 87 9.3. Biomedical Significance........................ 87 Chapter 10. Carboxylic Acids and Their Functional Derivatives........ ..89 10.1. Aliphatic and Aromatic Monocarboxylic Acids................ 89 10.1.1. Nomenclature........................... 89 10.1.2. Chemical Properties.......................... 91 10.2. Carbonic Acid Derivatives.................. .....103 10.3. Aliphatic and Aromatic Dicarboxylic Acids........... .......106 10.3.1. Classification and Nomenclature.................. ......106 10.3.2. Chemical Properties..................... ....107 Chapter 11. Biologically Important Heterofunctional Compounds...... ....110 11.1. Hydroxy Derivatives of Amines ............... ......110 11.1.1. Amino Alcohols........................ .......110 11.1.2. Aminophenols........................... 112 11.2. Hydroxy Acids.............................112 11.2.1. Aliphatic Hydroxy Acids.................... .....113 11.2.2. Aromatic Hydroxy Acids .................. ......119 11.3. Oxoacids......................... ......121 11.3.1. Some Representatives of Oxoacids................... 121 11.3.2. Biosynthesis of Higher Fatty Acids..................... 124 11.4. Amino Acids ...................... ......126 11.4.1. Structure of Amino Acids........................ 126 11.4.2. Nomenclature and Isomerism of Amino Acids............. .......126 11.4.3. Chemical Properties .................... .......127 11.5. Derivatives of Para-Amino Benzoic and Sulfanilic Acids ............ 131 PART ІII. BIOLOGICALLY ACTIVE HETEROCYCLIC COMPOUNDS........... 134 Chapter 12. Three-, Four- and five-membered Heterocyclic Compounds...... 134 12.1. Three- and four-membered Heterocyclic Compounds...... ........134 12.2. Five-Membered heterocycles containing one heteroatom ... ........136 12.2.1. Chemical Properties..................... .....136 12.2.2. Some Representatives Having Biomedical Significance......... .....139 12.3. Five-membered heterocycles containing two heteroatoms ......... 142 12.3.1. Oxazole and Isooxazole................... ......143 12.3.2. Thiazole............................... 143 12.3.3. Pyrazole............................... 144 12.3.4. The Most Important Derivatives of Pyrazole............ .......145 12.3.5. Imidazole.............................. 145 12.3.6. The Most Important Derivatives of Imidazole........... .......146 Chapter 13. Six- and seven-membered heterocyclic compounds......... 148 13.1. Six-Membered Heterocycles containing one heteroatom ........... 148 13.1.1. Six-Membered Heterocycles with Nitrogen Heteroatom....... ........148 13.1.2. Six-Membered Heterocycles with Oxygen Heteroatom ............... 155 13.2. Six-Membered Heterocycles containing two heteroatoms ... ........156 13.2.1. Six-Membered Heterocycles with Two Nitrogen Heteroatoms ...... ........156 13.2.2. Six-Membered Heterocycles with Nitrogen and Sulfur Heteroatoms .... ......160 13.3. Seven-Membered Heterocycles............... ........161 Chapter 14. Biologically Important Condensed Heterocyclic Systems, Alkaloids... 164 14.1. purine derivatives ..................... .......164 14.1.1. Hydroxy Derivatives of Purine................. .......165 14.1.2. Amino Derivatives of Purine........................ 167 14.2. pteridine derivatives ........................... 168 14.3. Alkaloids ................................. 169 14.3.3. Pyridine and Piperidine Alkaloids....................... 169 14.3.2. Quinoline Alkaloids...................... .......170 14.3.3. Isoquinoline and Phenanthrene Isoquinoline Alkaloids.............. 170 14.3.4. Tropane Alkaloids..................... .......171 PART ІV. BIOPOLYMERS AND BIOREGULATORS ......... .........174 Chapter 15. Carbohydrates or Saccharides (Sugars)............. .....174 15.1. Monosaccharides (Monoses)........................ 175 15.1.1. Isomerism.......................... .........176 15.1.2. Tautomerism......................... .........177 15.1.3. Chemical Properties ........................... 180 15.1.4. Individual Representatives......................... 189 15.1.5. Derivatives of Monosaccharides...................... 192 15.2. Disaccharides.............................. 194 15.2.1. Reducing Disaccharides..........................195 15.2.2. Non-Rreducing Disaccharides.................. .......201 15.3. Higher Polysaccharides..........................202 15.3.1. Homopolysaccharides .................... ........202 15.3.2. Heteropolysaccharides........................... 207 Chapter 16. Proteinogenic Amino Acids, Peptides and Proteins ........... 212 16.1. Proteinogenic amino acids and their properties ................ 212 16.1.1. Isomerism and Structure.................... ........212 16.1.2. Chemical Properties .............................216 16.2. Peptides and proteins ........................... 224 16.2.1. Amino Acid Composition and Amino Acid Sequence ........ .......224 16.2.2. Structural Organization of Proteins ....................... 228 16.2.3. Electrophoresis of Amino Acids and Proteins ............. ......233 16.2.4. Classification of Proteins ......................... 234 16.2.5. Qualitative Reactions on Proteins ...................... 235 Chapter 17. Nucleic Acids. Coenzymes.................. ......237 17.1. Nucleosides.............................. 239 17.2. Nucleotides............................... 240 17.3. The structure of Nucleic acids ....................... 241 17.3.1. The Primary Structure ................... .......241 17.3.2. The Secondary Structure of DNA............... .........243 17.3.3. The Structure and Functions of RNA...................... 245 17.4. Nucleotide Coenzymes ......................... 246 Chapter 18. Lipids.............................. 251 18.1. Saponifiable Lipids...................... ..........251 18.1.1. Simple Saponifiable Lipids........................... 251 18.1.2. Complex Saponifiable Lipids.......................... 254 18.2. Nonsaponifiable Lipids .................... ..........259 18.2.1. Terpenes................................ 259 18.2.2. Carotenoids........................ .......262 18.2.3. Steroids................................ 263 18.2.4. Prostaglandins ............................. 268 Answer on the Test for Self Control.......................... 271 Recommended Literature List............................ 272 INDEX............................... .......273
Дод.точки доступу:
Zimenkovsky, Boris Semenovich
Muzychenko, Volodymyr Afanasiiovych
Nizhenkovska, Iryna Volodymyrivna
Syrova, Ganna Olegivna
Zimenkovsky, Boris Semenovich \ред.\
Nizhenkovska, Iryna Volodymyrivna \ред.\

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ЧЗ (1), Уч.Аб. (1)
Вільні: ЧЗ (1), Уч.Аб. (1)

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10.

   577.1
   Г 68

    Hordiienko, L. P.
    Biological chemistry : сollection of test tasks : textbook / L. P. Hordiienko, M. V. Bilets, K. S. Neporada ; Ministry of public health of Ukraine, Ukrainian medical stomatological academy = Біологічна хімія : збірник тестових завдань : навчальний посібник / Л. П. Гордієнко, М. В. Білець, К. С. Непорада ; МОЗ України, УМСА. - Полтава/Poltava : Сімон, 2018 (Гаража М. Ф.). - 147 p. - На англ. мові. - ISBN 978-966-2989-79-6 : 025.00 грн
Обкл.: без авт., на англ. мові

УДК

577.1(075.8)

Рубрики: БИОХИМИЯ(АНГЛ)--навчальний посібник(англ)

Кл.слова (ненормовані):
навчальні посібники(англ)
Анотація: CONTENTS Module ІІ .................................... 7 1. Control of initial level of knowledge. The subject and tasks of biochemistry. The aim and methods of biochemical research, its clinical and diagnostic value .............. 7 2.Analysis of structure, physical and chemical properties of protein enzymes .......... 9 3. Measurement of enzymic activity. Units of catalytic activity of enzymes. Analysis of enzymic processes by the reaction type of main classes of enzymes ............... 11 4.Analysis of the mechanism of enzymic action and kinetics of enzymic catalysis ....... 13 5.Analysis of regulation of enzymic processes ..................... 16 6.Medical enzymology ............................... 18 7. Analysis of the role of cofactors and coenzyme vitamins (В2, РР, В6) in the catalytic activity of enzymes ..................................... 22 8. Analysis of the role of cofactors and coenzyme vitamins (В3, Вс, В1, В12, Н, lipoic acid) in the catalytic activity of enzymes ............................. 23 9. Basic concepts of metabolism. Common catabolic pathways of proteins, carbohydrates and lipids .................................... 26 10.Metabolism of substances and energy. Analysis of the tricarboxylic acid cycle ....... 28 11.Bioenergetics processes: biological oxidation, oxidative phosphorylation ......... 29 12. Chemiosmotic theory of oxidative phosphorylation. Inhibitors and uncouplers of oxidative phosphorylation .................................. 31 13.Analysis of glycolysis – anaerobic oxidation of carbohydrates ............ 33 14.Analysis of aerobic oxidation of glucose ...................... 36 15.Alternate pathways of monosaccharide metabolism. Metabolism of fructose and galactose ... 38 16.Analysis of catabolism and biosynthesis of glycogen. Regulation of glycogen metabolism ... 40 17.Gluconeogenesis .............................. 42 18.Analysis of mechanisms of metabolic and hormone regulation of carbohydrate metabolism . 44 19. Analysis of catabolism and biosynthesis of triacylglycerols. Determination of molecular mechanisms of regulation of lipolysis ........................ 46 20.Transport forms of lipids ............................. 48 21.β-oxidation of fatty acids. Analysis of metabolism of fatty acids and ketone bodies ...... 50 22.Biosynthesis of fatty acids ........................... 52 23.Metabolism of complex lipids ........................... 54 24. Biosynthesis and biotransformation of cholesterol. Analysis of disorders of lipid metabolism: steatorrhea, atherosclerosis, obesity ........................ 57 25.Analysis of amino acid metabolism (transamination, deamination, decarboxylation) .... 59 5 26.Biosynthesis of glutathione and creatine ....................... 61 27.Analysis of ammonia detoxication and urea biosynthesis .............. 63 28. Analysis of intermediate products of porphyrin biosynthesis and their accumulation at porphyrias .................................. 66 Module ІІІ ................................... 68 1.Structure and functions of nucleic acids....................... 68 2. Study of biosynthesis and catabolism of purine and pyrimidine nucleotides. Analysis of the end products of their metabolism ............................. 71 3.DNA replication and RNA transcription ...................... 74 4. Biosynthesis of proteins on ribosomes. Initiation, elongation and termination in the synthesis of polypeptide chain. Inhibitory action of antibiotics .................... 76 5.Regulation of gene expression ......................... 79 6.Analysis of mutation mechanisms, DNA reparation. Principles of synthesis of recombinat DNA, transgenic proteins ................................. 81 7. Study of molecular cellular mechanisms of action of peptide and protein hormones on target cells. Hormones of hypothalamus and hypophysis ................... 83 8. Study of molecular cellular mechanisms of action of steroid hormones on target cells. Steroid hormones ................................... 86 9.Study of role of thyroid hormones and biogenic amines in regulation of metabolic processes . 89 10.Hormones of pancreas. Hormones of the digestive tract ................ 91 11.Hormonal regulation of calcium homeostasis ..................... 93 12.Physiologically active eicosanoids ....................... 96 13.Study of digestion of nutrients: proteins, carbohydrates in the digestive tract ....... 98 14.Study of digestion of nutrients: lipids in the digestive tract ............. 100 15. Study of functional role of fat-soluble vitamins in the metabolism and realization of cell functions .................................. 102 16. Study of blood plasma proteins: proteins of acute phase of inflammation, own enzymes and indicator enzymes ................................ 105 17. Study of acid-base state of blood and respiratory function of erythrocytes. Pathological forms of hemoglobins ................................. 107 18. Study of nitrogen balance and non-protein nitrogen containing components of blood – end products of heme catabolism ........................... 110 19.Biochemical patterns of realization of immune processes. Immunodeficiency states ... 113 20.Biochemistry of liver. Pathobiochemistry of jaundices ................ 115 6 21. Study of processes of biotransformation of xenobiotics and endogeneous toxins. Microsomal oxidation, cytochrome P-450 .......................... 119 22.Study of normal components of urine. Study of pathological components of urine ...... 121 23.Biochemistry of muscle tissue ......................... 125 24.Biochemistry of connective tissue ......................... 127 25.Biochemistry of bone tissue. Risk factors of osteoporosis ............... 130 26.Biochemistry of nervous tissue .......................... 132 TESTS «BIOCHEMISTRY OF ORGANS OF ORAL CAVITY» ........... 135 Biochemistry of the dental tissue .......................... 135 Biochemistry of saliva ............................... 137 Biochemical mechanisms of the main stomatological diseases development ......... 138 ANSWERS TO THE TEST TASKS ........................ 143
Полный текст/внешний ресурс скачать: БД Електронний ресурс. № 277

Дод.точки доступу:
Bilets, M. V.
Білець М. В.
Neporada, K. S.
Непорада К.С.
Гордієнко Л. П.
UMSA (Poltava)

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