Б 63 Biological and bioorganical chemistry : teaching textbook / A. A. Mardashko, L. M. Mironovych, G. F. Stepanov, O. V. Storchilo. - K. : Caravela, 2020. - 240 p. : scheme. - На англ. мові. - References: p. 240. - ISBN 978-966-2229-05-9 : 050.00 грн. Переклад назви: Біологічна та біоорганічна хімія: навчальний посібник / О. О. Мардашко та ін.
Рубрики: БІОХІМІЯ(АНГЛ)--Навчальний посібник Кл.слова (ненормовані): навчальні посібники(англ) Анотація: CONTENTS Section I. Biologically important classes of bioorganic compounds. Biopolymers and their structural components....7 Chapter 1. Theoretical basis of the structure and reactivity of bioorganic compounds..............7 1.1. Classification, nomenclature and isomerism of bioorganic compounds. The nature of chemical bonds...........7 1.2. Classification of chemical reactions. Reactivity of alkanes, alkenes, arenes. alcohols, phenols, amines.......... 14 1.3. Structure and properties of aldehydes and ketones....... 19 1.4. Oxidation of aldehydes and ketones ...........22 1.4. Structure, properties and biological significance of carboxylic acids........................ 24 Chapter 2. Higher fatty acids. Lipids. Phospholipids. a-amino acids, peptides, proteins.................27 2.1. Higher fatty acids. Lipids. Phospholipids.........27 2.2. Amino acid composition of proteins and peptides........ 31 2.3. Structural organization of proteins. Physico-chemical properties of proteins. Reactions deposition of proteins. Denaturation Levels of the structure of protein molecules.............40 Chapter 3. Carbohydrates. Monosaccharides. Oligo-and polysaccharides ................45 3.1. Carbohydrates. The structure and chemical properties of monosaccharides....................45 Chapter 4. Biologically active heterocyclic compounds. Nucleosides, nucleotides, nucleic acids ............52 4.1. Classification, structure and significance of heterocyclic compounds....................... 52 4.2. Structure and biochemical functions of nucleosides and nucleotides....................... 60 4.3. Structure and biological role of nucleic acids.........61 Section II. The general pattern of metabolism.......... 65 Chapter 5. The biochemical components of cells........65 Chapter 6. Enzymes and coenzymes, coenzyme function of vitamins. Regulation of metabolism............68 6.1. Enzymes. Structure, physico-chemical properties of proteins. enzymes, classified by type of reaction ............68 6.2. Mechanism of action and determination of enzyme activity.... 70 6.3. Kinetics of enzymatic catalysis. Enzyme inhibitors..... 70 6.4. Cofactors and coenzymes. Coenzyme functions of vitamins ...72 Chapter 7. Basic laws of metabolism Citric acid cycle...... 74 7.1. Metabolism. Catabolism, anabolism. The general path of reform of proteins, carbohydrates, lipids.............74 7.2. Citric acid cycle .....................75 Chapter 8. Molecular Basis ofbioenergetics......... 77 8.1. Bioenergetics processes: biological oxidation, oxidative phosphorylation, ATP synthesis............... 77 8.2. Chemiosmotic theory of oxidative phosphorylation. Inhibitors and uncouplers of oxidative phosphorylation.... 80 8.3. Shuttle transport mechanisms across the membrane of mitochondria................... 86 8.4. The formation of free radicals, peroxides and antioxidants... 90 Section III. Metabolism of carbohydrates, lipids, aniino acids and its regulation.................93 Chapter 9. Carbohydrate metabolism and its regulation...... 93 9.1. Metabolism of carbohydrates. Anaerobic oxidation of glucose -glycolysis and glycogen - glycogenolysis...........93 9.2. Aerobic oxidation of glucose. Alternative ways of sharing monosaccharides. The metabolism of fructose and galactose. Pentose phosphate pathway...............97 9.3. Biosynthesis of glucose - gluconeogenesis and glycogen biosynthesis. Genetic metabolic glycogen......... 103 Chapter 10. Lipid metabolism and its regulation....... 10 8 10.1. Lipid Metabolism: catabolism of triacyl glycerols, the regulation of lipolysis. Metabolism of ketone bodies..................... 108 10.2. The biosynthesis of the active form of higher fatty acids.. 114 10 3 Biosynthesis and biotransformation of cholesterol, bile acids. Pathology of lipid metabolism: steatorreya, obesity, atherosclerosis................. . 119 Chapter 11. Metabolism ofamino acids. Enzymopathology ofamino acid metabolism..... 124 11.1. General ways ofamino acids transformation......... 125 11.2 Detoxication of ammonia, urea biosynthesis....... 129 11.3. Specialized ways of sharing the noncyclic and cyclic amino acids. The biosynthesis of glutathione and creatine. Enzymopathology ofamino acid metabolism........ 132 Section IV. Molecular Biology. Biochemistry of intercellular communication........... 141 Chapter 12. Fundamentals of molecular biology......... 141 12.1. Biochemical functions of nucleotides and nucleic acids ... 141 12.2. Biosynthesis and catabolism of purine and pyrimidine nucleotides. Hereditary metabolic uric acid disturbances.. 141 12.3. Enzymes and molecular mechanisms of DNA replication. Transcription - RNA biosynthesis............. 147 12.4. Protein biosynthesis in ribosomes. Stages and mechanism of translation, regulation of broadcasting. Antibiotics inhibitors of transcription and translation.............. 150 Chapter 13, Basics of molecular genetics............ 153 13.1. Regulation of gene expression in prokaryotes and eukaryotes 153 13.2. Molecular mechanisms of mutations. DNA reparation... 154 Chapter 14. Molecular mechanisms of hormones action on target cells................ 155 14.1. Molecular-cellular mechanisms of the hormonal signal transfer..................... 155 Chapter 15. Biochemistry hormonal regulation........ 159 15.1. Hormonal regulation of metabolism and cellular functions: the hormones of the hypothalamic-pituitary and thyroid gland. Regulation of calcium homeostasis ........... 159 15.2. Hormones of the pancreas. Regulation of carbohydrate metabolism...................... 16615.3. Hormones of adrenal and sex glands. Physiologically active eicosanoids........... 17o Section V. Biochemistry of tissues and physiological functions............ 133 Chapter 16. Biochemistry of human nutrition. Nutrition.... 183 16.1. Mechanisms of digestion of nutrients in the digestive tract. 183 16.2. Vitamins as components of nutrition: exogenous and endogenous hypovitaminosis........... 187 16.3. Lipid-soluble vitamins, antioxidants.......... 196 Chapter 17. Biochemistry andpatobioh emistry of blood...... 201 17.1. Biochemical composition of blood in health and disease: acute phase inflammatory proteins, enzymes of blood plasma............... 201 17.2. Non-proteinaceous nitrogen-containing and nitrogen-free organic components of blood. Plasma lipoproteins.....203 17.3. The respiratory function oferythrocytes. Acid-base status, the buffer system of blood ................205 17.4. Coagulant, anticoagulant and fibrtynolytic system of blood ...209 17.5. Biochemistry of immune processes and biochemical mechanisms of immunodeficiency condition.........216 Chapter 18. Functional and clinical biochemistry of organs and tissues............218 18.1. Biochemical functions of the liver. Porphyrin metabolism: the metabolism of bile pigments, Biochemistry ofjaundice.218 18.2. Biotransformation of xenobiotics and endogenous toxins in the liver: microsomal oxidation, cytochrome P-450...223 18.3. Urine production in kidney. Normal and pathological components of urine............ ...... 224 18.4. Biochemistry of muscle, muscle contraction and connective tissue......... .........229 18.5. Biochemistry of nervous tissue. Pathobiochemistry of mental disorders............ 235 REFERENCES............ -----240 Дод.точки доступу: Mardashko, A. A. Мардашко Олексій Олексійович Mironovych, L. M. Миронович Людмила Максимівна Stepanov, G. F. Степанов Генадій Федорович Storchilo, O. V. Сторчило Ольга В'ячеславівна Примірників всього: 2 ЧЗ (1), Наук.Аб. (1) Вільні: ЧЗ (1), Наук.Аб. (1) |